DegronMD

Uniprot ID: Q9Y6V0

Source protein: Protein piccolo

Source gene: PCLO

Class: DEG_SCF_FBW7_1

Location: 3942:3949

E3 ligase: FBXW7

DEGRON score: 0.8851

ASA_SCORE: 88.425

COIL: 0.96

CONS_SCORE: 0.4746

DSS_SCORE: 0.6023

HELIX: 0.0176

FCONS_SCORE: 0.8722

RIG_SCORE: 0.6431

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P3948T	TCGA-43-7656	LUSC	TCGA	PTPTPQPS	DEG_SCF_FBW7_1	0.5919
p.I3959M	TCGA-CK-6746	COAD	TCGA	PTPTPQPS	DEG_SCF_FBW7_1	0.0556
p.Q3939H	TCGA-IN-A6RO	STAD	TCGA	PTPTPQPS	DEG_SCF_FBW7_1	0.25
p.Q3941K	TCGA-JW-A5VL	CESC	TCGA	PTPTPQPS	DEG_SCF_FBW7_1	0.3056
p.M3956I	TCGA-W3-AA1V	SKCM	TCGA	PTPTPQPS	DEG_SCF_FBW7_1	0.1389
p.P3942H	ACH-000941	Endometrial/Uterine Cancer	CCLE	PTPTPQPS	DEG_SCF_FBW7_1	0.7694
p.M3957T	ACH-001030	Bone Cancer	CCLE	PTPTPQPS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6V0	Protein piccolo	DEG_SCF_FBW7_1	3942:3949	PTPTPQPS	FBXW7	0.8851	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons