DegronMD

Uniprot ID: Q9Y6V0

Source protein: Protein piccolo

Source gene: PCLO

Class: DEG_SCF_FBW7_1

Location: 3058:3064

E3 ligase: FBXW7

DEGRON score: 0.9679

ASA_SCORE: 74.5

COIL: 0.779

CONS_SCORE: 0.5109

DSS_SCORE: 0.5422

HELIX: 0.028

FCONS_SCORE: 0.951

RIG_SCORE: 0.702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R3067I	TCGA-AA-A00N	COAD	TCGA	ISTPQYS	DEG_SCF_FBW7_1	0.25
p.R3067I	DO9876	COAD	ICGC	ISTPQYS	DEG_SCF_FBW7_1	0.25
p.Q3062H	TCGA-AG-A002	READ	TCGA	ISTPQYS	DEG_SCF_FBW7_1	0.647
p.A3056T	TCGA-DM-A1HA	COAD	TCGA	ISTPQYS	DEG_SCF_FBW7_1	0.2778
p.A3056T	DO8754	COAD	ICGC	ISTPQYS	DEG_SCF_FBW7_1	0.2778
p.I3058M	TCGA-EI-6506	READ	TCGA	ISTPQYS	DEG_SCF_FBW7_1	0.6507
p.I3058M	DO36780	READ	ICGC	ISTPQYS	DEG_SCF_FBW7_1	0.6507
p.G3073R	TCGA-FW-A3R5	SKCM	TCGA	ISTPQYS	DEG_SCF_FBW7_1	0.0833
p.G3073R	DO37406	SKCM	ICGC	ISTPQYS	DEG_SCF_FBW7_1	0.0833
p.M3068L	TCGA-L5-A43E	ESCA	TCGA	ISTPQYS	DEG_SCF_FBW7_1	0.2222
p.M3068L	DO50355	ESAD	ICGC	ISTPQYS	DEG_SCF_FBW7_1	0.2222
p.M3068L	DO233773	GACA	ICGC	ISTPQYS	DEG_SCF_FBW7_1	0.2222
p.G3057R	TCGA-UC-A7PF	CESC	TCGA	ISTPQYS	DEG_SCF_FBW7_1	0.3056
p.G3057R	DO49987	CESC	ICGC	ISTPQYS	DEG_SCF_FBW7_1	0.3056
p.P3071T	DO228098	EOPC	ICGC	ISTPQYS	DEG_SCF_FBW7_1	0.1389
p.T3060N	DO228976	LICA	ICGC	ISTPQYS	DEG_SCF_FBW7_1	0.7055
p.T3065K	DO229022	LICA	ICGC	ISTPQYS	DEG_SCF_FBW7_1	0.3056
p.R3050P	DO231580	LINC	ICGC	ISTPQYS	DEG_SCF_FBW7_1	0.1111
p.G3055V	DO231906	LINC	ICGC	ISTPQYS	DEG_SCF_FBW7_1	0.25
p.A3056S	SIDM00498	Colorectal Carcinoma	GDSC	ISTPQYS	DEG_SCF_FBW7_1	0.2778
p.A3056S	ACH-000970	Colon/Colorectal Cancer	CCLE	ISTPQYS	DEG_SCF_FBW7_1	0.2778
p.A3056S	SNU-C5	large_intestine	COSMIC	ISTPQYS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6V0	Protein piccolo	DEG_SCF_FBW7_1	3058:3064	ISTPQYS	FBXW7	0.9679	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons