DegronMD

Uniprot ID: Q9Y6V0

Source protein: Protein piccolo

Source gene: PCLO

Class: DEG_SCF_FBW7_1

Location: 2178:2185

E3 ligase: FBXW7

DEGRON score: 0.9498

ASA_SCORE: 93.2375

COIL: 0.9508

CONS_SCORE: 0.3372

DSS_SCORE: 0.5554

HELIX: 0.0183

FCONS_SCORE: 0.993

RIG_SCORE: 0.6133

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2187F	TCGA-21-1071	LUSC	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	0.2778
p.S2187F	DO26918	LUSC	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	0.2778
p.D2180Y	TCGA-66-2769	LUSC	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	0.6214
p.D2180Y	DO26522	LUSC	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	0.6214
p.P2178H	TCGA-76-6286	GBM	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	0.7694
p.P2178H	DO13552	GBM	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	0.7694
p.S2190L	TCGA-D1-A103	UCEC	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	0.1944
p.S2190L	TCGA-EE-A181	SKCM	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	0.1944
p.S2190L	DO37444	SKCM	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	0.1944
p.S2190L	DO42312	UCEC	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	0.1944
p.S2190L	SIDM01060	Melanoma	GDSC	PSDTPSLT	DEG_SCF_FBW7_1	0.1944
p.S2190L	ACH-000882	Skin Cancer	CCLE	PSDTPSLT	DEG_SCF_FBW7_1	0.1944
p.S2190L	IGR-1	skin	COSMIC	PSDTPSLT	DEG_SCF_FBW7_1	0.1944
p.P2178L	TCGA-EE-A29M	SKCM	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	0.6471
p.P2178L	DO222702	MELA	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	0.6471
p.P2178L	DO37404	SKCM	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	0.6471
p.S2175F	TCGA-FR-A3YN	SKCM	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	0.25
p.S2175F	DO38111	SKCM	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	0.25
p.S2175F	SIDM01768	Melanoma	GDSC	PSDTPSLT	DEG_SCF_FBW7_1	0.25
p.S2175F	ACH-000899	Skin Cancer	CCLE	PSDTPSLT	DEG_SCF_FBW7_1	0.25
p.D2180N	TCGA-GN-A266	SKCM	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	0.5821
p.D2180N	DO37432	SKCM	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	0.5821
p.V2176I	TCGA-IG-A97H	ESCA	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	0.2778
p.T2174I	TCGA-QQ-A8VF	SARC	TCGA	PSDTPSLT	DEG_SCF_FBW7_1	0.2222
p.T2174I	DO220258	SARC	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	0.2222
p.E2168G	DO225331	BRCA	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	0.0556
p.S2186L	DO23104	LINC	ICGC	PSDTPSLT	DEG_SCF_FBW7_1	0.3056
p.S2186L	SIDM01175	Other Sarcomas	GDSC	PSDTPSLT	DEG_SCF_FBW7_1	0.3056
p.S2186L	ACH-002309	Sarcoma	CCLE	PSDTPSLT	DEG_SCF_FBW7_1	0.3056
p.S2186L	SW684	soft_tissue	COSMIC	PSDTPSLT	DEG_SCF_FBW7_1	0.3056
p.P2178T	SIDM00463	T-Lymphoblastic Leukemia	GDSC	PSDTPSLT	DEG_SCF_FBW7_1	0.7031
p.P2178T	ACH-000372	Leukemia	CCLE	PSDTPSLT	DEG_SCF_FBW7_1	0.7031
p.P2178T	P12-ICHIKAWA	haematopoietic_and_lymphoid_tissue	COSMIC	PSDTPSLT	DEG_SCF_FBW7_1	0.7031
p.P2178S	SIDM00694	Other Solid Cancers	GDSC	PSDTPSLT	DEG_SCF_FBW7_1	0.6752
p.P2178S	SIDM00673	Breast Carcinoma	GDSC	PSDTPSLT	DEG_SCF_FBW7_1	0.6752
p.T2174A	SIDM00214	Colorectal Carcinoma	GDSC	PSDTPSLT	DEG_SCF_FBW7_1	0.2222
p.T2174A	ACH-000955	Colon/Colorectal Cancer	CCLE	PSDTPSLT	DEG_SCF_FBW7_1	0.2222
p.T2174A	SNU-407	large_intestine	COSMIC	PSDTPSLT	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSDTPSLT

Degron related mutations and impact score

Drug responses associated with PCLO mutations

All proteins holding degron of PSDTPSLT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6V0	Protein piccolo	DEG_SCF_FBW7_1	2178:2185	PSDTPSLT	FBXW7	0.9498	More...