DegronMD

Uniprot ID: Q9Y6V0

Source protein: Protein piccolo

Source gene: PCLO

Class: DEG_SCF_TRCP1_1

Location: 3442:3447

E3 ligase: BTRC

DEGRON score: 0.9648

ASA_SCORE: 68.1167

COIL: 0.7478

CONS_SCORE: 0.4347

DSS_SCORE: 0.5601

HELIX: 0.0552

FCONS_SCORE: 0.8973

RIG_SCORE: 0.6858

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3456R	TCGA-05-4427	LUAD	TCGA	DSGVQT	DEG_SCF_TRCP1_1	0.0833
p.R3455Q	TCGA-18-3414	LUSC	TCGA	DSGVQT	DEG_SCF_TRCP1_1	0.1111
p.T3447M	TCGA-49-4505	LUAD	TCGA	DSGVQT	DEG_SCF_TRCP1_1	0.7423
p.T3447M	TCGA-HF-7132	STAD	TCGA	DSGVQT	DEG_SCF_TRCP1_1	0.7423
p.D3449N	TCGA-AA-A01T	COAD	TCGA	DSGVQT	DEG_SCF_TRCP1_1	0.2778
p.Q3446R	TCGA-AK-3456	KIRC	TCGA	DSGVQT	DEG_SCF_TRCP1_1	0.6218
p.R3435Q	TCGA-AP-A1DV	UCEC	TCGA	DSGVQT	DEG_SCF_TRCP1_1	0.1389
p.R3435Q	TCGA-CA-6718	COAD	TCGA	DSGVQT	DEG_SCF_TRCP1_1	0.1389
p.R3435Q	TCGA-ER-A198	SKCM	TCGA	DSGVQT	DEG_SCF_TRCP1_1	0.1389
p.R3435Q	TCGA-IG-A51D	ESCA	TCGA	DSGVQT	DEG_SCF_TRCP1_1	0.1389
p.T3453A	TCGA-B5-A3FA	UCEC	TCGA	DSGVQT	DEG_SCF_TRCP1_1	0.1667
p.D3451Y	TCGA-BS-A0UF	UCEC	TCGA	DSGVQT	DEG_SCF_TRCP1_1	0.2222
p.R3455W	TCGA-D3-A8GI	SKCM	TCGA	DSGVQT	DEG_SCF_TRCP1_1	0.1111
p.E3450K	TCGA-FW-A3R5	SKCM	TCGA	DSGVQT	DEG_SCF_TRCP1_1	0.25
p.D3432N	SIDM00433	T-Lymphoblastic Leukemia	GDSC	DSGVQT	DEG_SCF_TRCP1_1	0.0556
p.D3432N	SIDM01483	Melanoma	GDSC	DSGVQT	DEG_SCF_TRCP1_1	0.0556
p.D3432N	SIDM01149	Small Cell Lung Carcinoma	GDSC	DSGVQT	DEG_SCF_TRCP1_1	0.0556
p.D3454Y	SIDM00789	Colorectal Carcinoma	GDSC	DSGVQT	DEG_SCF_TRCP1_1	0.1389
p.D3454Y	HCT-15	large_intestine	COSMIC	DSGVQT	DEG_SCF_TRCP1_1	0.1389
p.S3436N	SIDM00567	Other Solid Cancers	GDSC	DSGVQT	DEG_SCF_TRCP1_1	0.1667
p.S3436N	ACH-000776	Brain Cancer	CCLE	DSGVQT	DEG_SCF_TRCP1_1	0.1667
p.S3436N	ONS-76	central_nervous_system	COSMIC	DSGVQT	DEG_SCF_TRCP1_1	0.1667
p.D3449E	SIDM01205	Acute Myeloid Leukemia	GDSC	DSGVQT	DEG_SCF_TRCP1_1	0.2778
p.D3449E	SIDM01195	Acute Myeloid Leukemia	GDSC	DSGVQT	DEG_SCF_TRCP1_1	0.2778
p.D3449E	ACH-000406	Leukemia	CCLE	DSGVQT	DEG_SCF_TRCP1_1	0.2778
p.D3449E	ACH-002314	Leukemia	CCLE	DSGVQT	DEG_SCF_TRCP1_1	0.2778
p.D3449E	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	DSGVQT	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RD6	Pannexin-2	DEG_SCF_TRCP1_1	399:404	DSGVQT	BTRC	0.9965	More...
Q9Y6V0	Protein piccolo	DEG_SCF_TRCP1_1	3442:3447	DSGVQT	BTRC	0.9648	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGVQT

Degron related mutations and impact score

Drug responses associated with PCLO mutations

All proteins holding degron of DSGVQT