DegronMD

Uniprot ID: Q96RD6

Source protein: Pannexin-2

Source gene: PANX2

Class: DEG_SCF_TRCP1_1

Location: 399:404

E3 ligase: BTRC

DEGRON score: 0.9965

ASA_SCORE: 80.8333

COIL: 0.8283

CONS_SCORE: 0.9526

DSS_SCORE: 0.6795

HELIX: 0.0492

FCONS_SCORE: 1.233

RIG_SCORE: 0.6442

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D392A	DO230312	COCA	ICGC	DSGVQT	DEG_SCF_TRCP1_1	0.1389
p.A412T	DO222853	COCA	ICGC	DSGVQT	DEG_SCF_TRCP1_1	0.1111
p.V405L	DO228766	LICA	ICGC	DSGVQT	DEG_SCF_TRCP1_1	0.3056
p.P411L	DO229177	LMS	ICGC	DSGVQT	DEG_SCF_TRCP1_1	0.1389
p.D392N	DO220906	MELA	ICGC	DSGVQT	DEG_SCF_TRCP1_1	0.1389
p.T394I	SIDM01119	Other Solid Cancers	GDSC	DSGVQT	DEG_SCF_TRCP1_1	0.1944
p.T394I	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	DSGVQT	DEG_SCF_TRCP1_1	0.1944
p.P414S	ACH-000779	Lung Cancer	CCLE	DSGVQT	DEG_SCF_TRCP1_1	0.0556
p.N410T	ACH-000880	Gastric Cancer	CCLE	DSGVQT	DEG_SCF_TRCP1_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons