DegronMD

Uniprot ID: Q9Y6V0

Source protein: Protein piccolo

Source gene: PCLO

Class: DEG_SCF_FBW7_1

Location: 3093:3099

E3 ligase: FBXW7

DEGRON score: 0.992

ASA_SCORE: 73.5

COIL: 0.7846

CONS_SCORE: 0.5519

DSS_SCORE: 0.2893

HELIX: 0.02

FCONS_SCORE: 1.2387

RIG_SCORE: 0.7499

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3085Y	TCGA-06-2563	GBM	TCGA	VATPTPS	DEG_SCF_FBW7_1	0.1111
p.S3085Y	DO11525	GBM	ICGC	VATPTPS	DEG_SCF_FBW7_1	0.1111
p.G3108C	TCGA-DJ-A2PX	THCA	TCGA	VATPTPS	DEG_SCF_FBW7_1	0.0833
p.G3108C	DO39683	THCA	ICGC	VATPTPS	DEG_SCF_FBW7_1	0.0833
p.P3096L	TCGA-FS-A4F0	SKCM	TCGA	VATPTPS	DEG_SCF_FBW7_1	0.7582
p.P3096L	DO37891	SKCM	ICGC	VATPTPS	DEG_SCF_FBW7_1	0.7582
p.S3092L	TCGA-IR-A3LK	CESC	TCGA	VATPTPS	DEG_SCF_FBW7_1	0.3056
p.S3092L	DO44299	CESC	ICGC	VATPTPS	DEG_SCF_FBW7_1	0.3056
p.S3091F	TCGA-YD-A9TA	SKCM	TCGA	VATPTPS	DEG_SCF_FBW7_1	0.2778
p.S3091F	DO219503	SKCM	ICGC	VATPTPS	DEG_SCF_FBW7_1	0.2778
p.S3099F	DO233289	GACA	ICGC	VATPTPS	DEG_SCF_FBW7_1	0.7982
p.P3096A	DO26469	LUSC	ICGC	VATPTPS	DEG_SCF_FBW7_1	0.7503
p.V3089A	SIDM01259	B-Lymphoblastic Leukemia	GDSC	VATPTPS	DEG_SCF_FBW7_1	0.2222
p.V3089A	ACH-001669	Leukemia	CCLE	VATPTPS	DEG_SCF_FBW7_1	0.2222
p.V3089A	ACH-002238	Leukemia	CCLE	VATPTPS	DEG_SCF_FBW7_1	0.2222
p.V3089A	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	VATPTPS	DEG_SCF_FBW7_1	0.2222
p.S3091P	SIDM01043	Other Sarcomas	GDSC	VATPTPS	DEG_SCF_FBW7_1	0.2778
p.S3091P	ESS-1	endometrium	COSMIC	VATPTPS	DEG_SCF_FBW7_1	0.2778
p.G3108V	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VATPTPS	DEG_SCF_FBW7_1	0.0833
p.G3108V	ACH-000916	Lung Cancer	CCLE	VATPTPS	DEG_SCF_FBW7_1	0.0833
p.G3108V	NCI-H1573	lung	COSMIC	VATPTPS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6V0	Protein piccolo	DEG_SCF_FBW7_1	3093:3099	VATPTPS	FBXW7	0.992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons