DegronMD

Uniprot ID: Q9Y6V0

Source protein: Protein piccolo

Source gene: PCLO

Class: DEG_APCC_DBOX_1

Location: 1578:1586

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8076

ASA_SCORE: 106.0333

COIL: 0.5758

CONS_SCORE: 0.4555

DSS_SCORE: 0.6039

HELIX: 0.3994

FCONS_SCORE: 1.0465

RIG_SCORE: 0.7318

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1588T	TCGA-33-4587	LUSC	TCGA	IRNQLKEIS	DEG_APCC_DBOX_1	0.2778
p.S1588T	DO27683	LUSC	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	0.2778
p.S1587C	TCGA-95-7567	LUAD	TCGA	IRNQLKEIS	DEG_APCC_DBOX_1	0.3056
p.S1587C	DO25564	LUAD	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	0.3056
p.K1593T	TCGA-B5-A3FA	UCEC	TCGA	IRNQLKEIS	DEG_APCC_DBOX_1	0.25
p.K1593T	DO23214	LINC	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	0.25
p.K1593T	DO52402	UCEC	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	0.25
p.S1572F	TCGA-BF-AAP7	SKCM	TCGA	IRNQLKEIS	DEG_APCC_DBOX_1	0.1667
p.S1572F	DO219472	SKCM	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	0.1667
p.E1595K	TCGA-EE-A2MJ	SKCM	TCGA	IRNQLKEIS	DEG_APCC_DBOX_1	0.0833
p.E1595K	TCGA-EE-A2MU	SKCM	TCGA	IRNQLKEIS	DEG_APCC_DBOX_1	0.0833
p.E1595K	DO37436	SKCM	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	0.0833
p.E1595K	DO38099	SKCM	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	0.0833
p.E1595K	ACH-000987	Skin Cancer	CCLE	IRNQLKEIS	DEG_APCC_DBOX_1	0.0833
p.E1595K	Mewo	skin	COSMIC	IRNQLKEIS	DEG_APCC_DBOX_1	0.0833
p.D1575E	DO222953	BTCA	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	0.25
p.K1593N	DO50447	ESAD	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	0.25
p.E1576A	DO234270	ESAD	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	0.2778
p.R1579T	DO234166	ESAD	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	0.7876
p.Q1592K	DO229026	LICA	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	0.1667
p.R1579K	DO222402	MELA	ICGC	IRNQLKEIS	DEG_APCC_DBOX_1	0.7237
p.E1576K	SIDM01156	Small Cell Lung Carcinoma	GDSC	IRNQLKEIS	DEG_APCC_DBOX_1	0.2778
p.E1576K	SIDM01203	Other Solid Cancers	GDSC	IRNQLKEIS	DEG_APCC_DBOX_1	0.2778
p.E1576K	ACH-000890	Lung Cancer	CCLE	IRNQLKEIS	DEG_APCC_DBOX_1	0.2778
p.E1576K	ACH-002291	Embryonal Cancer	CCLE	IRNQLKEIS	DEG_APCC_DBOX_1	0.2778
p.E1576K	SW1271	lung	COSMIC	IRNQLKEIS	DEG_APCC_DBOX_1	0.2778
p.E1576K	NTERA-2_cl_D1	testis	COSMIC	IRNQLKEIS	DEG_APCC_DBOX_1	0.2778
p.E1590K	SIDM00189	Melanoma	GDSC	IRNQLKEIS	DEG_APCC_DBOX_1	0.2222
p.E1590K	ACH-002098	Skin Cancer	CCLE	IRNQLKEIS	DEG_APCC_DBOX_1	0.2222
p.E1590K	CP67-MEL	skin	COSMIC	IRNQLKEIS	DEG_APCC_DBOX_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRNQLKEIS

Degron related mutations and impact score

Drug responses associated with PCLO mutations

All proteins holding degron of IRNQLKEIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6V0	Protein piccolo	DEG_APCC_DBOX_1	1578:1586	IRNQLKEIS	APC,CDC20,FZR1	0.8076	More...