DegronMD

Uniprot ID: Q9Y6V0

Source protein: Protein piccolo

Source gene: PCLO

Class: DEG_SCF_FBW7_1

Location: 920:926

E3 ligase: FBXW7

DEGRON score: 0.986

ASA_SCORE: 98.0429

COIL: 0.9151

CONS_SCORE: 0.5182

DSS_SCORE: 0.6379

HELIX: 0.0306

FCONS_SCORE: 1.0452

RIG_SCORE: 0.7006

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A915S	TCGA-18-3417	LUSC	TCGA	PTTPQET	DEG_SCF_FBW7_1	0.1944
p.A915S	TCGA-55-7994	LUAD	TCGA	PTTPQET	DEG_SCF_FBW7_1	0.1944
p.A915S	DO45311	LUAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.1944
p.A915S	DO26584	LUSC	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.1944
p.V927M	TCGA-AX-A3G9	UCEC	TCGA	PTTPQET	DEG_SCF_FBW7_1	0.3056
p.V927M	TCGA-DM-A1D4	COAD	TCGA	PTTPQET	DEG_SCF_FBW7_1	0.3056
p.V927M	DO10782	COAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.3056
p.V927M	DO41241	UCEC	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.3056
p.I912N	TCGA-B0-5099	KIRC	TCGA	PTTPQET	DEG_SCF_FBW7_1	0.1111
p.I912N	DO16317	KIRC	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.1111
p.S911N	TCGA-CN-A498	HNSC	TCGA	PTTPQET	DEG_SCF_FBW7_1	0.0833
p.S911N	DO52038	HNSC	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.0833
p.K922N	DO218990	BLCA	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.6918
p.K922N	DO50406	ESAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.6918
p.K922N	DO233235	GACA	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.6918
p.K922N	DO38635	STAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.6918
p.R930T	DO4921	BRCA	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.3333
p.I926T	DO8264	COAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.7078
p.F923Y	DO234157	ESAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.7528
p.K922Q	DO234270	ESAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.6944
p.E933G	DO234315	ESAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.1389
p.F923V	DO223116	ESCA	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.7068
p.R930G	DO233245	GACA	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.3333
p.F923C	DO233288	GACA	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.7108
p.F923C	DO47879	STAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.7108
p.S921T	DO220519	KICH	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.7116
p.K910R	DO20516	KIRC	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.0556
p.S929G	DO232008	LICA	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.25
p.L915I	DO219582	LIHC	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.1944
p.G935V	DO23378	LINC	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.0833
p.D935Y	DO25545	LUAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.0833
p.E933Q	DO219144	LUSC	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.1389
p.G910E	DO220877	MELA	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.0556
p.S924L	DO220895	MELA	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.7667
p.S924L	DO222662	MELA	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.7667
p.S924L	DO37444	SKCM	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.7667
p.S924L	DO219503	SKCM	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.7667
p.P916S	DO220899	MELA	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.2222
p.K922I	DO38839	STAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.7531
p.Y936S	DO38839	STAD	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.0556
p.K912N	DO219773	UCEC	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.1111
p.F923L	DO43041	UCEC	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.6981
p.K922T	DO41903	UCEC	ICGC	PTTPQET	DEG_SCF_FBW7_1	0.7306
p.F932C	SIDM00955	Melanoma	GDSC	PTTPQET	DEG_SCF_FBW7_1	0.1667
p.F932C	ACH-000812	Skin Cancer	CCLE	PTTPQET	DEG_SCF_FBW7_1	0.1667
p.F932C	COLO-783	skin	COSMIC	PTTPQET	DEG_SCF_FBW7_1	0.1667
p.P916L	SIDM00973	Melanoma	GDSC	PTTPQET	DEG_SCF_FBW7_1	0.2222
p.P916L	ACH-000827	Skin Cancer	CCLE	PTTPQET	DEG_SCF_FBW7_1	0.2222
p.P916L	WM793B	skin	COSMIC	PTTPQET	DEG_SCF_FBW7_1	0.2222
p.A915T	SIDM01146	Gastric Carcinoma	GDSC	PTTPQET	DEG_SCF_FBW7_1	0.1944
p.A915T	ACH-000932	Gastric Cancer	CCLE	PTTPQET	DEG_SCF_FBW7_1	0.1944
p.A915T	NCI-SNU-1	stomach	COSMIC	PTTPQET	DEG_SCF_FBW7_1	0.1944
p.T922A	SIDM00528	Breast Carcinoma	GDSC	PTTPQET	DEG_SCF_FBW7_1	0.7139
p.T922A	ACH-000934	Breast Cancer	CCLE	PTTPQET	DEG_SCF_FBW7_1	0.7139
p.T922A	MDA-MB-361	breast	COSMIC	PTTPQET	DEG_SCF_FBW7_1	0.7139
p.G935A	SIDM01472	Hepatocellular Carcinoma	GDSC	PTTPQET	DEG_SCF_FBW7_1	0.0833
p.G935A	ACH-000471	Liver Cancer	CCLE	PTTPQET	DEG_SCF_FBW7_1	0.0833
p.K913N	SW684	soft_tissue	COSMIC	PTTPQET	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTTPQET

Degron related mutations and impact score

Drug responses associated with PCLO mutations

All proteins holding degron of PTTPQET

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6V0	Protein piccolo	DEG_SCF_FBW7_1	920:926	PTTPQET	FBXW7	0.986	More...