DegronMD

Uniprot ID: Q9Y6V0

Source protein: Protein piccolo

Source gene: PCLO

Class: DEG_SCF_FBW7_1

Location: 889:895

E3 ligase: FBXW7

DEGRON score: 0.996

ASA_SCORE: 102.6571

COIL: 0.9727

CONS_SCORE: 0.6191

DSS_SCORE: 0.9308

HELIX: 0.0114

FCONS_SCORE: 1.1098

RIG_SCORE: 0.5836

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S895F	TCGA-18-3409	LUSC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	0.7982
p.S895F	DO26444	LUSC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.7982
p.T891K	TCGA-2Y-A9HA	LIHC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	0.7306
p.T891K	DO219539	LIHC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.7306
p.R882L	TCGA-44-6778	LUAD	TCGA	VPTPQQS	DEG_SCF_FBW7_1	0.1389
p.R882L	DO25603	LUAD	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.1389
p.G886V	TCGA-66-2795	LUSC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	0.25
p.G886V	DO26710	LUSC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.25
p.A885T	TCGA-A5-A0G2	UCEC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	0.2222
p.A885T	TCGA-C5-A1MI	CESC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	0.2222
p.A885T	DO6249	CESC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.2222
p.A885T	DO41235	UCEC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.2222
p.A885T	SIDM02059	Colorectal Carcinoma	GDSC	VPTPQQS	DEG_SCF_FBW7_1	0.2222
p.K897N	TCGA-B5-A1MR	UCEC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	0.2778
p.K897N	DO41758	UCEC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.2778
p.R882Q	TCGA-BR-8680	STAD	TCGA	VPTPQQS	DEG_SCF_FBW7_1	0.1389
p.R882Q	TCGA-FR-A726	SKCM	TCGA	VPTPQQS	DEG_SCF_FBW7_1	0.1389
p.R882Q	DO48665	SKCM	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.1389
p.R882Q	DO47769	STAD	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.1389
p.R882Q	ACH-002396	Bone Cancer	CCLE	VPTPQQS	DEG_SCF_FBW7_1	0.1389
p.R882Q	Sarc9371	bone	COSMIC	VPTPQQS	DEG_SCF_FBW7_1	0.1389
p.R904C	TCGA-C5-A7X3	CESC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	0.0833
p.R904C	TCGA-CN-6992	HNSC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	0.0833
p.R904C	DO49893	CESC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.0833
p.R904C	DO14606	HNSC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.0833
p.S902L	TCGA-CV-A45Z	HNSC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	0.1389
p.S902L	DO52064	HNSC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.1389
p.P892R	TCGA-D6-A4Z9	HNSC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	0.7512
p.P892R	DO44419	HNSC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.7512
p.E900D	TCGA-QS-A5YQ	UCEC	TCGA	VPTPQQS	DEG_SCF_FBW7_1	0.1944
p.E900D	DO49073	UCEC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.1944
p.S902P	TCGA-XK-AAIW	PRAD	TCGA	VPTPQQS	DEG_SCF_FBW7_1	0.1389
p.S902P	DO51407	PRAD	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.1389
p.A901S	DO8463	COAD	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.1667
p.K893N	DO230346	COCA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.6918
p.Q898H	DO228491	GACA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.25
p.T891I	DO233885	GACA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.7078
p.S885N	DO233855	GACA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.2222
p.G880C	DO228217	LICA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.0833
p.G880C	SIDM00652	Small Cell Lung Carcinoma	GDSC	VPTPQQS	DEG_SCF_FBW7_1	0.0833
p.G880C	ACH-000780	Lung Cancer	CCLE	VPTPQQS	DEG_SCF_FBW7_1	0.0833
p.G880C	NCI-H1105	lung	COSMIC	VPTPQQS	DEG_SCF_FBW7_1	0.0833
p.T884N	DO228974	LICA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.1944
p.Q887K	DO229034	LICA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.2778
p.E882D	DO24190	LUAD	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.1389
p.S881Y	DO232761	PBCA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.1111
p.A902V	DO51407	PRAD	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.1389
p.A902V	DO51299	SKCM	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.1389
p.Y884H	DO46869	RECA	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.1944
p.P879S	DO37814	SKCM	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.0556
p.A901V	DO223282	UCEC	ICGC	VPTPQQS	DEG_SCF_FBW7_1	0.1667
p.T888S	SIDM00364	B-Lymphoblastic Leukemia	GDSC	VPTPQQS	DEG_SCF_FBW7_1	0.3056
p.T888S	ACH-002059	Leukemia	CCLE	VPTPQQS	DEG_SCF_FBW7_1	0.3056
p.T888S	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	VPTPQQS	DEG_SCF_FBW7_1	0.3056
p.P896T	SIDM00282	Colorectal Carcinoma	GDSC	VPTPQQS	DEG_SCF_FBW7_1	0.3056
p.P896T	ACH-000998	Colon/Colorectal Cancer	CCLE	VPTPQQS	DEG_SCF_FBW7_1	0.3056
p.P896T	CW-2	large_intestine	COSMIC	VPTPQQS	DEG_SCF_FBW7_1	0.3056
p.I903R	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	VPTPQQS	DEG_SCF_FBW7_1	0.1111
p.E892K	Mewo	skin	COSMIC	VPTPQQS	DEG_SCF_FBW7_1	0.7022

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPTPQQS

Degron related mutations and impact score

Drug responses associated with PCLO mutations

All proteins holding degron of VPTPQQS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6V0	Protein piccolo	DEG_SCF_FBW7_1	889:895	VPTPQQS	FBXW7	0.996	More...