DegronMD

Uniprot ID: Q9Y6V0

Source protein: Protein piccolo

Source gene: PCLO

Class: DEG_SCF_FBW7_1

Location: 2589:2595

E3 ligase: FBXW7

DEGRON score: 0.8503

ASA_SCORE: 84.4143

COIL: 0.9536

CONS_SCORE: 0.4508

DSS_SCORE: 0.5439

HELIX: 0.0176

FCONS_SCORE: 1.0499

RIG_SCORE: 0.6416

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2592Q	TCGA-AD-6895	COAD	TCGA	PGTPTDS	DEG_SCF_FBW7_1	0.7035
p.P2592Q	DO8938	COAD	ICGC	PGTPTDS	DEG_SCF_FBW7_1	0.7035
p.S2595Y	TCGA-BS-A0UV	UCEC	TCGA	PGTPTDS	DEG_SCF_FBW7_1	0.712
p.S2595Y	DO42793	UCEC	ICGC	PGTPTDS	DEG_SCF_FBW7_1	0.712
p.T2579P	TCGA-D7-6822	STAD	TCGA	PGTPTDS	DEG_SCF_FBW7_1	0.0556
p.T2579P	DO38423	STAD	ICGC	PGTPTDS	DEG_SCF_FBW7_1	0.0556
p.Q2599H	TCGA-DM-A280	COAD	TCGA	PGTPTDS	DEG_SCF_FBW7_1	0.2222
p.Q2599H	DO8256	COAD	ICGC	PGTPTDS	DEG_SCF_FBW7_1	0.2222
p.P2592L	TCGA-EE-A29R	SKCM	TCGA	PGTPTDS	DEG_SCF_FBW7_1	0.7582
p.P2592L	DO37448	SKCM	ICGC	PGTPTDS	DEG_SCF_FBW7_1	0.7582
p.T2591I	TCGA-GN-A265	SKCM	TCGA	PGTPTDS	DEG_SCF_FBW7_1	0.7078
p.T2591I	DO227657	COCA	ICGC	PGTPTDS	DEG_SCF_FBW7_1	0.7078
p.T2591I	DO37491	SKCM	ICGC	PGTPTDS	DEG_SCF_FBW7_1	0.7078
p.P2605L	TCGA-SX-A71S	KIRP	TCGA	PGTPTDS	DEG_SCF_FBW7_1	0.0556
p.P2605L	DO49778	KIRP	ICGC	PGTPTDS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6V0	Protein piccolo	DEG_SCF_FBW7_1	2589:2595	PGTPTDS	FBXW7	0.8503	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons