DegronMD

Uniprot ID: Q9Y6V0

Source protein: Protein piccolo

Source gene: PCLO

Class: DEG_COP1_1

Location: 4655:4665

E3 ligase: COP1

DEGRON score: 0.9237

ASA_SCORE: 78.0909

COIL: 0.9257

CONS_SCORE: 0.7468

DSS_SCORE: 0.7418

HELIX: 0.0187

FCONS_SCORE: 1.0213

RIG_SCORE: 0.4881

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S4664I	TCGA-05-4382	LUAD	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.7341
p.S4664I	DO24900	LUAD	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.7341
p.T4655K	TCGA-05-4398	LUAD	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.7306
p.T4655K	DO25847	LUAD	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.7306
p.P4671T	TCGA-18-3411	LUSC	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.1667
p.P4671T	DO26758	LUSC	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.1667
p.S4661F	TCGA-21-1079	LUSC	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.6871
p.S4661F	TCGA-CN-A6V7	HNSC	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.6871
p.S4661F	DO218997	HNSC	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.6871
p.S4661F	DO26846	LUSC	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.6871
p.S4661F	DO222521	MELA	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.6871
p.V4662F	TCGA-55-A490	LUAD	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.7068
p.V4662F	DO24596	LUAD	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.7068
p.P4668L	TCGA-56-5897	LUSC	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.25
p.P4668L	DO26453	LUSC	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.25
p.G4653C	TCGA-66-2734	LUSC	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.2778
p.G4653C	TCGA-BF-A1PX	SKCM	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.2778
p.G4653C	DO26430	LUSC	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.2778
p.G4653C	DO51236	SKCM	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.2778
p.G4669R	TCGA-BF-AAOU	SKCM	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.2222
p.G4669R	DO219460	SKCM	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.2222
p.G4647E	TCGA-D3-A2J8	SKCM	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.1111
p.G4647E	TCGA-EE-A29V	SKCM	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.1111
p.G4647E	TCGA-SY-A9G5	BLCA	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.1111
p.G4647E	DO51906	BLCA	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.1111
p.G4647E	DO37778	SKCM	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.1111
p.G4647E	DO38006	SKCM	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.1111
p.G4666W	TCGA-D3-A2JK	SKCM	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.3056
p.G4666W	DO230539	LUSC	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.3056
p.G4666W	DO37619	SKCM	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.3056
p.P4665H	TCGA-DX-A1KU	SARC	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.7694
p.P4665H	DO219944	SARC	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.7694
p.G4647R	TCGA-EE-A29V	SKCM	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.1111
p.G4647R	DO222653	MELA	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.1111
p.G4647R	DO222843	MELA	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.1111
p.G4647R	DO38006	SKCM	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.1111
p.S4674N	TCGA-EJ-5515	PRAD	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.0833
p.S4674N	DO36251	PRAD	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.0833
p.S4670C	TCGA-S9-A6WM	LGG	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.1944
p.S4670C	DO50200	LGG	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.1944
p.S4652L	TCGA-VR-A8EY	ESCA	TCGA	TSAGSSSVPSP	DEG_COP1_1	0.25
p.S4670Y	DO229028	LICA	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.1944
p.S4648Y	DO229028	LICA	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.1389
p.A4657T	DO50869	LICA	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.6028
p.P4671R	DO45091	LIRI	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.1667
p.S4670P	DO228253	MALY	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.1944
p.H4651Y	DO220891	MELA	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.2222
p.H4651Y	DO222632	MELA	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.2222
p.P4654S	DO222837	MELA	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.3056
p.S4670F	DO229465	SKCA	ICGC	TSAGSSSVPSP	DEG_COP1_1	0.1944
p.V4673M	SIDM00967	Ovarian Carcinoma	GDSC	TSAGSSSVPSP	DEG_COP1_1	0.1111
p.P4654H	ACH-001664	Gastric Cancer	CCLE	TSAGSSSVPSP	DEG_COP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TSAGSSSVPSP

Degron related mutations and impact score

Drug responses associated with PCLO mutations

All proteins holding degron of TSAGSSSVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6V0	Protein piccolo	DEG_COP1_1	4655:4665	TSAGSSSVPSP	COP1	0.9237	More...