DegronMD

Uniprot ID: Q9Y6V0

Source protein: Protein piccolo

Source gene: PCLO

Class: LIG_APCC_ABBAyCdc20_2

Location: 1688:1694

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8572

ASA_SCORE: 106.6143

COIL: 0.833

CONS_SCORE: 0.569

DSS_SCORE: 0.5809

HELIX: 0.1356

FCONS_SCORE: 0.9533

RIG_SCORE: 0.7375

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1682S	TCGA-05-4417	LUAD	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.1667
p.A1682S	DO23570	LUAD	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.1667
p.Q1686R	TCGA-55-7576	LUAD	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.Q1686R	DO24431	LUAD	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.D1694E	TCGA-92-8065	LUSC	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.5647
p.D1694E	DO27074	LUSC	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.5647
p.D1694H	TCGA-AR-A2LE	BRCA	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.7688
p.D1694H	DO1932	BRCA	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.7688
p.M1701T	TCGA-B5-A0K6	UCEC	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.1389
p.M1701T	DO40808	UCEC	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E1698K	TCGA-CV-5966	HNSC	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E1698K	DO14950	HNSC	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E1698K	ACH-000544	Esophageal Cancer	CCLE	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D1678N	TCGA-GC-A3OO	BLCA	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.D1678N	DO518	BLCA	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P1697A	TCGA-VR-A8EY	ESCA	TCGA	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.25
p.Q1686K	DO229038	LICA	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.L1691M	DO23478	LINC	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.5999
p.T1689K	DO25104	LUAD	ICGC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.6195
p.E1696K	SIDM00333	Endometrial Carcinoma	GDSC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E1696K	ACH-000988	Endometrial/Uterine Cancer	CCLE	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E1696K	MFE-319	endometrium	COSMIC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.2778
p.M1701I	SIDM01088	Endometrial Carcinoma	GDSC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.1389
p.M1701I	ACH-000965	Endometrial/Uterine Cancer	CCLE	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.1389
p.M1701I	RL95-2	endometrium	COSMIC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.1389
p.S1690R	SIDM01611	Endometrial Carcinoma	GDSC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.6316
p.S1690R	ACH-000996	Endometrial/Uterine Cancer	CCLE	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.6316
p.P1697L	SIDM01525	Acute Myeloid Leukemia	GDSC	KTSLYFD	LIG_APCC_ABBAyCdc20_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KTSLYFD

Degron related mutations and impact score

Drug responses associated with PCLO mutations

All proteins holding degron of KTSLYFD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6V0	Protein piccolo	LIG_APCC_ABBAyCdc20_2	1688:1694	KTSLYFD	APC,CDC20,FZR1	0.8572	More...