DegronMD

Uniprot ID: Q9Y6V0

Source protein: Protein piccolo

Source gene: PCLO

Class: DEG_COP1_1

Location: 3174:3184

E3 ligase: COP1

DEGRON score: 0.9701

ASA_SCORE: 71.2727

COIL: 0.7327

CONS_SCORE: 0.6513

DSS_SCORE: 0.3475

HELIX: 0.1426

FCONS_SCORE: 0.9798

RIG_SCORE: 0.8012

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T3169S	TCGA-94-A5I6	LUSC	TCGA	TAETIDSVPTL	DEG_COP1_1	0.1944
p.T3169S	DO219176	LUSC	ICGC	TAETIDSVPTL	DEG_COP1_1	0.1944
p.I3178V	TCGA-A5-A0G2	UCEC	TCGA	TAETIDSVPTL	DEG_COP1_1	0.5965
p.I3178V	DO41235	UCEC	ICGC	TAETIDSVPTL	DEG_COP1_1	0.5965
p.S3180Y	TCGA-AP-A0LM	UCEC	TCGA	TAETIDSVPTL	DEG_COP1_1	0.6009
p.S3180Y	DO43306	UCEC	ICGC	TAETIDSVPTL	DEG_COP1_1	0.6009
p.D3179H	TCGA-BA-5555	HNSC	TCGA	TAETIDSVPTL	DEG_COP1_1	0.6577
p.D3179H	DO14220	HNSC	ICGC	TAETIDSVPTL	DEG_COP1_1	0.6577
p.S3180F	TCGA-D3-A8GI	SKCM	TCGA	TAETIDSVPTL	DEG_COP1_1	0.6871
p.S3180F	TCGA-W3-A824	SKCM	TCGA	TAETIDSVPTL	DEG_COP1_1	0.6871
p.S3180F	DO229453	SKCA	ICGC	TAETIDSVPTL	DEG_COP1_1	0.6871
p.S3180F	DO50284	SKCM	ICGC	TAETIDSVPTL	DEG_COP1_1	0.6871
p.S3180F	DO51271	SKCM	ICGC	TAETIDSVPTL	DEG_COP1_1	0.6871
p.V3181F	TCGA-DK-AA77	BLCA	TCGA	TAETIDSVPTL	DEG_COP1_1	0.7068
p.V3181F	DO219014	BLCA	ICGC	TAETIDSVPTL	DEG_COP1_1	0.7068
p.P3182S	TCGA-EE-A3AD	SKCM	TCGA	TAETIDSVPTL	DEG_COP1_1	0.6752
p.P3182S	DO37707	SKCM	ICGC	TAETIDSVPTL	DEG_COP1_1	0.6752
p.S3172Y	TCGA-EO-A22X	UCEC	TCGA	TAETIDSVPTL	DEG_COP1_1	0.2778
p.S3172Y	DO222798	COCA	ICGC	TAETIDSVPTL	DEG_COP1_1	0.2778
p.S3172Y	DO43907	UCEC	ICGC	TAETIDSVPTL	DEG_COP1_1	0.2778
p.T3169N	TCGA-EO-A22X	UCEC	TCGA	TAETIDSVPTL	DEG_COP1_1	0.1944
p.T3169N	DO43907	UCEC	ICGC	TAETIDSVPTL	DEG_COP1_1	0.1944
p.P3192S	TCGA-FS-A1ZA	SKCM	TCGA	TAETIDSVPTL	DEG_COP1_1	0.1111
p.P3192S	DO37551	SKCM	ICGC	TAETIDSVPTL	DEG_COP1_1	0.1111
p.E3189K	TCGA-FT-A3EE	BLCA	TCGA	TAETIDSVPTL	DEG_COP1_1	0.1944
p.E3189K	DO720	BLCA	ICGC	TAETIDSVPTL	DEG_COP1_1	0.1944
p.E3189K	Sarc9371	bone	COSMIC	TAETIDSVPTL	DEG_COP1_1	0.1944
p.V3181L	TCGA-S7-A7X1	PCPG	TCGA	TAETIDSVPTL	DEG_COP1_1	0.6765
p.A3187T	SIDM00120	Prostate Carcinoma	GDSC	TAETIDSVPTL	DEG_COP1_1	0.25
p.A3187T	ACH-000979	Prostate Cancer	CCLE	TAETIDSVPTL	DEG_COP1_1	0.25
p.A3187T	DU-145	prostate	COSMIC	TAETIDSVPTL	DEG_COP1_1	0.25
p.L3165F	SIDM00719	Small Cell Lung Carcinoma	GDSC	TAETIDSVPTL	DEG_COP1_1	0.0833
p.S3164N	SIDM00719	Small Cell Lung Carcinoma	GDSC	TAETIDSVPTL	DEG_COP1_1	0.0556
p.T3186K	ACH-000068	Lymphoma	CCLE	TAETIDSVPTL	DEG_COP1_1	0.2778
p.T3177S	ACH-001558	Lung Cancer	CCLE	TAETIDSVPTL	DEG_COP1_1	0.6005

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: TAETIDSVPTL

Degron related mutations and impact score

Drug responses associated with PCLO mutations

All proteins holding degron of TAETIDSVPTL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6V0	Protein piccolo	DEG_COP1_1	3174:3184	TAETIDSVPTL	COP1	0.9701	More...