DegronMD

Uniprot ID: A7MD48

Source protein: Serine/arginine repetitive matrix protein 4

Source gene: SRRM4

Class: DEG_SCF_TRCP1_1

Location: 329:335

E3 ligase: BTRC

DEGRON score: 0.996

ASA_SCORE: 86.3571

COIL: 0.9271

CONS_SCORE: 0.872

DSS_SCORE: 0.725

HELIX: 0.0377

FCONS_SCORE: 1.6719

RIG_SCORE: 0.5597

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N332T	DO50342	ESAD	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	0.5944
p.T336A	DO234321	ESAD	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	0.3056
p.S328F	DO233941	GACA	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	0.3056
p.N326S	TCGA-QK-A8Z7	HNSC	TCGA	DSGNSFT	DEG_SCF_TRCP1_1	0.25
p.N326S	DO52096	HNSC	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	0.25
p.N326Y	DO220893	MELA	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	0.25
p.P339T	TCGA-60-2726	LUSC	TCGA	DSGNSFT	DEG_SCF_TRCP1_1	0.2222
p.P339T	DO27484	LUSC	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	0.2222
p.Q340L	DO233129	GACA	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	0.1944
p.Q340H	DO229032	LICA	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	0.1944
p.S324C	SIDM00845	Burkitt's Lymphoma	GDSC	DSGNSFT	DEG_SCF_TRCP1_1	0.1944
p.E321Q	DO23250	LINC	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	0.1111
p.G343E	DO229453	SKCA	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	0.1111
p.A344V	TCGA-AA-3947	COAD	TCGA	DSGNSFT	DEG_SCF_TRCP1_1	0.0833
p.A344V	DO8192	COAD	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	0.0833
p.R320Q	TCGA-CM-6169	COAD	TCGA	DSGNSFT	DEG_SCF_TRCP1_1	0.0833
p.R320Q	DO8344	COAD	ICGC	DSGNSFT	DEG_SCF_TRCP1_1	0.0833
p.R320Q	SIDM00951	T-Lymphoblastic Leukemia	GDSC	DSGNSFT	DEG_SCF_TRCP1_1	0.0833
p.R320Q	SIDM01580	Melanoma	GDSC	DSGNSFT	DEG_SCF_TRCP1_1	0.0833
p.S319I	SIDM00570	Gastric Carcinoma	GDSC	DSGNSFT	DEG_SCF_TRCP1_1	0.0556
p.S319I	ACH-000674	Gastric Cancer	CCLE	DSGNSFT	DEG_SCF_TRCP1_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MD48	Serine/arginine repetitive matrix protein 4	DEG_SCF_TRCP1_1	329:335	DSGNSFT	BTRC	0.996	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons