DegronMD

Uniprot ID: A7MD48

Source protein: Serine/arginine repetitive matrix protein 4

Source gene: SRRM4

Class: DEG_SCF_TRCP1_1

Location: 286:292

E3 ligase: BTRC

DEGRON score: 0.9941

ASA_SCORE: 92.0429

COIL: 0.9476

CONS_SCORE: 0.9615

DSS_SCORE: 0.7934

HELIX: 0.0391

FCONS_SCORE: 1.5032

RIG_SCORE: 0.5388

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S287L	SIDM01782	Oral Cavity Carcinoma	GDSC	DSGNDTS	DEG_SCF_TRCP1_1	0.7667
p.S287L	ACH-000723	Head and Neck Cancer	CCLE	DSGNDTS	DEG_SCF_TRCP1_1	0.7667
p.G288E	TCGA-55-A494	LUAD	TCGA	DSGNDTS	DEG_SCF_TRCP1_1	0.7199
p.G288E	DO23794	LUAD	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	0.7199
p.G288E	DO222837	MELA	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	0.7199
p.D286N	DO233935	GACA	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	0.6932
p.S292A	TCGA-60-2708	LUSC	TCGA	DSGNDTS	DEG_SCF_TRCP1_1	0.6477
p.S292A	DO26431	LUSC	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	0.6477
p.Q283H	TCGA-AP-A1DK	UCEC	TCGA	DSGNDTS	DEG_SCF_TRCP1_1	0.25
p.Q283H	DO42033	UCEC	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	0.25
p.S282F	TCGA-06-5416	GBM	TCGA	DSGNDTS	DEG_SCF_TRCP1_1	0.2222
p.S282F	DO10880	GBM	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	0.2222
p.R281L	DO229029	LICA	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	0.1944
p.R279P	TCGA-55-8302	LUAD	TCGA	DSGNDTS	DEG_SCF_TRCP1_1	0.1389
p.R279P	DO45312	LUAD	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	0.1389
p.S300N	TCGA-B5-A1MX	UCEC	TCGA	DSGNDTS	DEG_SCF_TRCP1_1	0.1111
p.S300N	DO41999	UCEC	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	0.1111
p.A302S	TCGA-DK-A2I1	BLCA	TCGA	DSGNDTS	DEG_SCF_TRCP1_1	0.0556
p.A302S	DO444	BLCA	ICGC	DSGNDTS	DEG_SCF_TRCP1_1	0.0556

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MD48	Serine/arginine repetitive matrix protein 4	DEG_SCF_TRCP1_1	286:292	DSGNDTS	BTRC	0.9941	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons