DegronMD - Q14246(ADGRE1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T885M	SIDM00557	Neuroblastoma	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	872:880	Mutation rewiring degron network	0.1944
p.T885M	SIDM00778	Colorectal Carcinoma	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	872:880	Mutation rewiring degron network	0.1944
p.T885M	SIDM00849	Kidney Carcinoma	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	872:880	Mutation rewiring degron network	0.1944
p.T885M	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	872:880	Mutation rewiring degron network	0.1944
p.T885M	SIDM01686	Chronic Myelogenous Leukemia	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	872:880	Mutation rewiring degron network	0.1944
p.T885M	SIDM01752	Pancreatic Carcinoma	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	872:880	Mutation rewiring degron network	0.1944
p.P880T	SIDM00694	Other Solid Cancers	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	872:880	Mutation altering degron motif	0.5919
p.Q870E	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	872:880	Mutation rewiring degron network	0.2778
p.Q870E	NCI-H1734	lung	COSMIC	SRILLSSMP	DEG_APCC_DBOX_1	872:880	Mutation rewiring degron network	0.2778
p.M511I	SIDM00140	Melanoma	GDSC	PLTTS	DEG_SPOP_SBC_1	501:505	Mutation rewiring degron network	0.1667
p.M511I	COLO-792	skin	COSMIC	PLTTS	DEG_SPOP_SBC_1	501:505	Mutation rewiring degron network	0.1667
p.H498N	SIDM00220	Ovarian Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	501:505	Mutation rewiring degron network	0.25
p.H498N	OC-314	ovary	COSMIC	PLTTS	DEG_SPOP_SBC_1	501:505	Mutation rewiring degron network	0.25
p.T511I	SBC-3	lung	COSMIC	PLTTS	DEG_SPOP_SBC_1	501:505	Mutation rewiring degron network	0.1667
p.F494L	SHP-77	lung	COSMIC	PLTTS	DEG_SPOP_SBC_1	501:505	Mutation rewiring degron network	0.1389
p.L515F	HCC1569	breast	COSMIC	PLTTS	DEG_SPOP_SBC_1	501:505	Mutation rewiring degron network	0.0556

Kaplan plot for ADGRE1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADGRE1

UniProt ID: Q14246

Entrez ID: 2015

Protein name: Adhesion G protein-coupled receptor E1 (EGF-like module receptor 1) (EGF-like module-containing mucin-like hormone receptor-like 1) (EMR1 hormone receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADGRE1 in