DegronMD

Uniprot ID: Q14246

Source protein: Adhesion G protein-coupled receptor E1

Source gene: ADGRE1

Class: DEG_APCC_DBOX_1

Location: 872:880

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.539

ASA_SCORE: 104.3

COIL: 0.7817

CONS_SCORE: 0.5198

DSS_SCORE: 0.6706

HELIX: 0.023

FCONS_SCORE: 1.1491

RIG_SCORE: 0.7067

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T885M	SIDM00557	Neuroblastoma	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	0.1944
p.T885M	SIDM00778	Colorectal Carcinoma	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	0.1944
p.T885M	SIDM00849	Kidney Carcinoma	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	0.1944
p.T885M	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	0.1944
p.T885M	SIDM01686	Chronic Myelogenous Leukemia	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	0.1944
p.T885M	SIDM01752	Pancreatic Carcinoma	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	0.1944
p.P880T	SIDM00694	Other Solid Cancers	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	0.5919
p.Q870E	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	SRILLSSMP	DEG_APCC_DBOX_1	0.2778
p.Q870E	NCI-H1734	lung	COSMIC	SRILLSSMP	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14246	Adhesion G protein-coupled receptor E1	DEG_APCC_DBOX_1	872:880	SRILLSSMP	APC,CDC20,FZR1	0.539	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons