DegronMD

Uniprot ID: Q5SW79

Source protein: Centrosomal protein of 170 kDa

Source gene: CEP170

Class: DEG_SPOP_SBC_1

Location: 562:566

E3 ligase: SPOP

DEGRON score: 0.994

ASA_SCORE: 90.84

COIL: 0.878

CONS_SCORE: 0.4398

DSS_SCORE: 0.5238

HELIX: 0.0846

FCONS_SCORE: 1.0713

RIG_SCORE: 0.6681

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E558K	TCGA-AR-A2LE	BRCA	TCGA	PLTTS	DEG_SPOP_SBC_1	0.2222
p.G574S	TCGA-CQ-6223	HNSC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.1111
p.S576Y	TCGA-EO-A22R	UCEC	TCGA	PLTTS	DEG_SPOP_SBC_1	0.0556
p.V565I	DO48996	CESC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.7076
p.E558D	DO10300	COAD	ICGC	PLTTS	DEG_SPOP_SBC_1	0.2222
p.K563N	DO7828	COAD	ICGC	PLTTS	DEG_SPOP_SBC_1	0.6918
p.K563N	TE-9	oesophagus	COSMIC	PLTTS	DEG_SPOP_SBC_1	0.6918
p.Q567L	DO45449	LUSC	ICGC	PLTTS	DEG_SPOP_SBC_1	0.3056
p.G567E	SIDM00814	Other Solid Cancers	GDSC	PLTTS	DEG_SPOP_SBC_1	0.3056
p.G567E	ACH-001401	Adrenal Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	0.3056
p.G567E	SW13	adrenal_gland	COSMIC	PLTTS	DEG_SPOP_SBC_1	0.3056
p.H569L	ACH-000774	Lung Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	0.25
p.Q567E	U-698-M	haematopoietic_and_lymphoid_tissue	COSMIC	PLTTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MD48	Serine/arginine repetitive matrix protein 4	DEG_SPOP_SBC_1	274:278	PLTTS	SPOP	0.9836	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	300:304	PLTTS	SPOP	0.9856	More...
P29074	Tyrosine-protein phosphatase non-receptor type 4	DEG_SPOP_SBC_1	919:923	PLTTS	SPOP	0.847	More...
Q14246	Adhesion G protein-coupled receptor E1	DEG_SPOP_SBC_1	501:505	PLTTS	SPOP	0.7492	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	562:566	PLTTS	SPOP	0.994	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	187:191	PLTTS	SPOP	0.968	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9734:9738	PLTTS	SPOP	0.8464	More...
Q9NQU5	Serine/threonine-protein kinase PAK 6	DEG_SPOP_SBC_1	320:324	PLTTS	SPOP	0.9576	More...
Q9P107	GEM-interacting protein	DEG_SPOP_SBC_1	779:783	PLTTS	SPOP	0.6642	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	715:719	PLTTS	SPOP	0.9997	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	1997:2001	PLTTS	SPOP	0.9692	More...
Q9Y2D9	Zinc finger protein 652	DEG_SPOP_SBC_1	507:511	PLTTS	SPOP	0.9882	More...
Q9P2C4	Transmembrane protein 181	DEG_SPOP_SBC_1	47:51	PLTTS	SPOP	0.6212	More...
Q0P670	Uncharacterized protein SPEM2	DEG_SPOP_SBC_1	397:401	PLTTS	SPOP	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons