DegronMD - Q9P107(GMIP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R223C	TCGA-19-1787	GBM	TCGA	RRAQLQYVQ	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.3056
p.R223C	DO13522	GBM	ICGC	RRAQLQYVQ	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.3056
p.R228W	TCGA-22-4604	LUSC	TCGA	RRAQLQYVQ	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.1667
p.R228W	DO26922	LUSC	ICGC	RRAQLQYVQ	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.1667
p.R214W	TCGA-CK-5916	COAD	TCGA	RRAQLQYVQ	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.7523
p.R214W	DO8786	COAD	ICGC	RRAQLQYVQ	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.7523
p.R230H	TCGA-CV-7261	HNSC	TCGA	RRAQLQYVQ	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.1111
p.R230H	DO15062	HNSC	ICGC	RRAQLQYVQ	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.1111
p.Q217K	TCGA-DZ-6133	KIRP	TCGA	RRAQLQYVQ	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.5833
p.Q217K	DO20762	KIRP	ICGC	RRAQLQYVQ	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.5833
p.P777T	TCGA-F7-A624	HNSC	TCGA	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.2778
p.P789L	TCGA-FI-A2D0	UCEC	TCGA	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.1667
p.D792N	TCGA-PK-A5HB	ACC	TCGA	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.0833
p.S231F	TCGA-ZX-AA5X	CESC	TCGA	RRAQLQYVQ	DEG_APCC_DBOX_1	214:222	Mutation blocking phosphorylation signal	0.5278
p.S231F	DO219762	CESC	ICGC	RRAQLQYVQ	DEG_APCC_DBOX_1	214:222	Mutation blocking phosphorylation signal	0.5278
p.T793R	DO222878	BTCA	ICGC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.0556
p.H785R	DO44440	HNSC	ICGC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.2778
p.Q790H	DO228916	LICA	ICGC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.1389
p.P772S	DO228947	LICA	ICGC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.1389
p.P772S	DO230522	LUSC	ICGC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.1389
p.P772S	DO231102	LUSC	ICGC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.1389
p.T787N	DO228976	LICA	ICGC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.2222
p.A229E	DO52665	MALY	ICGC	RRAQLQYVQ	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.1389
p.S769F	DO47569	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.0556
p.Q770R	DO47833	STAD	ICGC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.0833
p.S774I	SIDM00135	Breast Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.1944
p.S774I	SIDM01123	Prostate Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.1944
p.S774I	SIDM00841	Colorectal Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.1944
p.S774I	SIDM00534	Colorectal Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.1944
p.S774I	SIDM01566	Hodgkin's Lymphoma	GDSC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.1944
p.P770H	SIDM01125	Non-Small Cell Lung Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.0833
p.P770H	ACH-000378	Lung Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation rewiring degron network	0.0833
p.P779L	SIDM01596	Non-Small Cell Lung Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation altering degron motif	0.7582
p.P779L	ACH-000066	Lung Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	779:783	Mutation altering degron motif	0.7582
p.V210L	ACH-001664	Gastric Cancer	CCLE	RRAQLQYVQ	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.2222
p.E208D	ACH-002048	Sarcoma	CCLE	RRAQLQYVQ	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.1667

Kaplan plot for GMIP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GMIP

UniProt ID: Q9P107

Entrez ID: 51291

Protein name: GEM-interacting protein (GMIP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GMIP in