DegronMD

Uniprot ID: Q9P107

Source protein: GEM-interacting protein

Source gene: GMIP

Class: DEG_APCC_DBOX_1

Location: 214:222

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9517

ASA_SCORE: 83.2

COIL: 0.0112

CONS_SCORE: 0.4911

DSS_SCORE: 0.4587

HELIX: 0.9888

FCONS_SCORE: 1.1695

RIG_SCORE: 0.7887

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R223C	TCGA-19-1787	GBM	TCGA	RRAQLQYVQ	DEG_APCC_DBOX_1	0.3056
p.R223C	DO13522	GBM	ICGC	RRAQLQYVQ	DEG_APCC_DBOX_1	0.3056
p.R228W	TCGA-22-4604	LUSC	TCGA	RRAQLQYVQ	DEG_APCC_DBOX_1	0.1667
p.R228W	DO26922	LUSC	ICGC	RRAQLQYVQ	DEG_APCC_DBOX_1	0.1667
p.R214W	TCGA-CK-5916	COAD	TCGA	RRAQLQYVQ	DEG_APCC_DBOX_1	0.7523
p.R214W	DO8786	COAD	ICGC	RRAQLQYVQ	DEG_APCC_DBOX_1	0.7523
p.R230H	TCGA-CV-7261	HNSC	TCGA	RRAQLQYVQ	DEG_APCC_DBOX_1	0.1111
p.R230H	DO15062	HNSC	ICGC	RRAQLQYVQ	DEG_APCC_DBOX_1	0.1111
p.Q217K	TCGA-DZ-6133	KIRP	TCGA	RRAQLQYVQ	DEG_APCC_DBOX_1	0.5833
p.Q217K	DO20762	KIRP	ICGC	RRAQLQYVQ	DEG_APCC_DBOX_1	0.5833
p.S231F	TCGA-ZX-AA5X	CESC	TCGA	RRAQLQYVQ	DEG_APCC_DBOX_1	0.5278
p.S231F	DO219762	CESC	ICGC	RRAQLQYVQ	DEG_APCC_DBOX_1	0.5278
p.A229E	DO52665	MALY	ICGC	RRAQLQYVQ	DEG_APCC_DBOX_1	0.1389
p.V210L	ACH-001664	Gastric Cancer	CCLE	RRAQLQYVQ	DEG_APCC_DBOX_1	0.2222
p.E208D	ACH-002048	Sarcoma	CCLE	RRAQLQYVQ	DEG_APCC_DBOX_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P107	GEM-interacting protein	DEG_APCC_DBOX_1	214:222	RRAQLQYVQ	APC,CDC20,FZR1	0.9517	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons