DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 187:191

E3 ligase: SPOP

DEGRON score: 0.968

ASA_SCORE: 91.4

COIL: 0.8628

CONS_SCORE: 0.5236

DSS_SCORE: 0.5038

HELIX: 0.0166

FCONS_SCORE: 0.9948

RIG_SCORE: 0.7015

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P187S	TCGA-FW-A3R5	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	0.6752
p.P187S	DO37406	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	0.6752
p.S195R	TCGA-VQ-A94R	STAD	TCGA	PLTTS	DEG_SPOP_SBC_1	0.2222
p.S195R	DO222372	STAD	ICGC	PLTTS	DEG_SPOP_SBC_1	0.2222
p.L178F	TCGA-Z2-A8RT	SKCM	TCGA	PLTTS	DEG_SPOP_SBC_1	0.0833
p.L178F	DO51301	SKCM	ICGC	PLTTS	DEG_SPOP_SBC_1	0.0833
p.S191F	DO224920	BRCA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.7982
p.T199I	DO234321	ESAD	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1111
p.S196L	DO220877	MELA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.1944
p.P187L	DO47174	RECA	ICGC	PLTTS	DEG_SPOP_SBC_1	0.7582
p.A194E	SIDM00506	Small Cell Lung Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.25
p.A194E	COR-L88	lung	COSMIC	PLTTS	DEG_SPOP_SBC_1	0.25
p.A194T	SIDM00118	Colorectal Carcinoma	GDSC	PLTTS	DEG_SPOP_SBC_1	0.25
p.A194T	ACH-001081	Colon/Colorectal Cancer	CCLE	PLTTS	DEG_SPOP_SBC_1	0.25
p.A194T	HCC2998	large_intestine	COSMIC	PLTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7MD48	Serine/arginine repetitive matrix protein 4	DEG_SPOP_SBC_1	274:278	PLTTS	SPOP	0.9836	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	300:304	PLTTS	SPOP	0.9856	More...
P29074	Tyrosine-protein phosphatase non-receptor type 4	DEG_SPOP_SBC_1	919:923	PLTTS	SPOP	0.847	More...
Q14246	Adhesion G protein-coupled receptor E1	DEG_SPOP_SBC_1	501:505	PLTTS	SPOP	0.7492	More...
Q5SW79	Centrosomal protein of 170 kDa	DEG_SPOP_SBC_1	562:566	PLTTS	SPOP	0.994	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	187:191	PLTTS	SPOP	0.968	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	9734:9738	PLTTS	SPOP	0.8464	More...
Q9NQU5	Serine/threonine-protein kinase PAK 6	DEG_SPOP_SBC_1	320:324	PLTTS	SPOP	0.9576	More...
Q9P107	GEM-interacting protein	DEG_SPOP_SBC_1	779:783	PLTTS	SPOP	0.6642	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	715:719	PLTTS	SPOP	0.9997	More...
Q96RV3	Pecanex-like protein 1	DEG_SPOP_SBC_1	1997:2001	PLTTS	SPOP	0.9692	More...
Q9Y2D9	Zinc finger protein 652	DEG_SPOP_SBC_1	507:511	PLTTS	SPOP	0.9882	More...
Q9P2C4	Transmembrane protein 181	DEG_SPOP_SBC_1	47:51	PLTTS	SPOP	0.6212	More...
Q0P670	Uncharacterized protein SPEM2	DEG_SPOP_SBC_1	397:401	PLTTS	SPOP	0.9988	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons