DegronMD

Uniprot ID: O15018

Source protein: PDZ domain-containing protein 2

Source gene: PDZD2

Class: DEG_SCF_TRCP1_1

Location: 2032:2037

E3 ligase: BTRC

DEGRON score: 0.9983

ASA_SCORE: 76.8667

COIL: 0.9495

CONS_SCORE: 0.4214

DSS_SCORE: 0.6954

HELIX: 0.0293

FCONS_SCORE: 1.3061

RIG_SCORE: 0.5673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C2022Y	TCGA-13-0905	OV	TCGA	DSGPVS	DEG_SCF_TRCP1_1	0.0556
p.C2022Y	DO31490	OV	ICGC	DSGPVS	DEG_SCF_TRCP1_1	0.0556
p.R2023K	TCGA-BH-A2L8	BRCA	TCGA	DSGPVS	DEG_SCF_TRCP1_1	0.0833
p.R2023K	DO44242	BRCA	ICGC	DSGPVS	DEG_SCF_TRCP1_1	0.0833
p.E2025Q	TCGA-DK-AA74	BLCA	TCGA	DSGPVS	DEG_SCF_TRCP1_1	0.1389
p.E2025Q	DO219011	BLCA	ICGC	DSGPVS	DEG_SCF_TRCP1_1	0.1389
p.A2039V	DO222769	COCA	ICGC	DSGPVS	DEG_SCF_TRCP1_1	0.2778
p.G2044S	DO234230	ESAD	ICGC	DSGPVS	DEG_SCF_TRCP1_1	0.1389
p.R2030H	DO233270	GACA	ICGC	DSGPVS	DEG_SCF_TRCP1_1	0.2778
p.V2047M	DO220844	MELA	ICGC	DSGPVS	DEG_SCF_TRCP1_1	0.0556
p.G2034R	SIDM01652	Non-Cancerous	GDSC	DSGPVS	DEG_SCF_TRCP1_1	0.7568
p.G2034R	SIDM00187	Kidney Carcinoma	GDSC	DSGPVS	DEG_SCF_TRCP1_1	0.7568
p.A2031V	SIDM00079	Ovarian Carcinoma	GDSC	DSGPVS	DEG_SCF_TRCP1_1	0.3056
p.A2031V	ACH-000811	Ovarian Cancer	CCLE	DSGPVS	DEG_SCF_TRCP1_1	0.3056
p.A2031V	SK-OV-3	ovary	COSMIC	DSGPVS	DEG_SCF_TRCP1_1	0.3056
p.P2035L	SIDM00451	T-Lymphoblastic Leukemia	GDSC	DSGPVS	DEG_SCF_TRCP1_1	0.6471
p.P2035L	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	DSGPVS	DEG_SCF_TRCP1_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SCF_TRCP1_1	2032:2037	DSGPVS	BTRC	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons