DegronMD

Uniprot ID: O15018

Source protein: PDZ domain-containing protein 2

Source gene: PDZD2

Class: LIG_APCC_ABBA_1

Location: 1584:1589

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7794

ASA_SCORE: 110.5833

COIL: 0.8938

CONS_SCORE: 0.3401

DSS_SCORE: 0.6995

HELIX: 0.0763

FCONS_SCORE: 0.9596

RIG_SCORE: 0.6121

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1576S	TCGA-22-4593	LUSC	TCGA	VSLHKE	LIG_APCC_ABBA_1	0.1111
p.G1576S	DO27018	LUSC	ICGC	VSLHKE	LIG_APCC_ABBA_1	0.1111
p.G1576S	DO222504	MELA	ICGC	VSLHKE	LIG_APCC_ABBA_1	0.1111
p.G1576S	SIDM00781	Colorectal Carcinoma	GDSC	VSLHKE	LIG_APCC_ABBA_1	0.1111
p.G1576S	SIDM00780	Colorectal Carcinoma	GDSC	VSLHKE	LIG_APCC_ABBA_1	0.1111
p.G1576S	SNU-C2B	large_intestine	COSMIC	VSLHKE	LIG_APCC_ABBA_1	0.1111
p.R1581C	TCGA-BH-A0AY	BRCA	TCGA	VSLHKE	LIG_APCC_ABBA_1	0.25
p.R1581C	DO5025	BRCA	ICGC	VSLHKE	LIG_APCC_ABBA_1	0.25
p.K1588N	TCGA-BR-8361	STAD	TCGA	VSLHKE	LIG_APCC_ABBA_1	0.5806
p.K1588N	DO48032	STAD	ICGC	VSLHKE	LIG_APCC_ABBA_1	0.5806
p.D1575N	TCGA-EE-A20C	SKCM	TCGA	VSLHKE	LIG_APCC_ABBA_1	0.0833
p.D1575N	DO222775	MELA	ICGC	VSLHKE	LIG_APCC_ABBA_1	0.0833
p.D1575N	DO47665	SKCM	ICGC	VSLHKE	LIG_APCC_ABBA_1	0.0833
p.E1597Q	TCGA-VS-A953	CESC	TCGA	VSLHKE	LIG_APCC_ABBA_1	0.1111
p.E1597Q	DO219727	CESC	ICGC	VSLHKE	LIG_APCC_ABBA_1	0.1111
p.S1594L	SIDM01199	Hepatocellular Carcinoma	GDSC	VSLHKE	LIG_APCC_ABBA_1	0.6389
p.S1594L	ACH-000493	Liver Cancer	CCLE	VSLHKE	LIG_APCC_ABBA_1	0.6389
p.S1594L	SNU-423	liver	COSMIC	VSLHKE	LIG_APCC_ABBA_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	LIG_APCC_ABBA_1	1584:1589	VSLHKE	APC,CDC20,FZR1	0.7794	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons