DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NGQGIYSVKP
Uniprot ID:
O15018
Source protein:
PDZ domain-containing protein 2
Source gene:
PDZD2
Class:
CBL_PTK
Location:
2273:2282
E3 ligase:
CBL
DEGRON score:
0.719
ASA_SCORE:
82.73
COIL:
0.7861
CONS_SCORE:
0.2933
DSS_SCORE:
0.3688
HELIX:
0.0303
FCONS_SCORE:
1.018
RIG_SCORE:
0.7436
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P2282S
TCGA-AX-A06F
UCEC
TCGA
NGQGIYSVKP
CBL_PTK
0.6752
p.P2282S
DO41752
UCEC
ICGC
NGQGIYSVKP
CBL_PTK
0.6752
p.P2282S
SIDM00216
Colorectal Carcinoma
GDSC
NGQGIYSVKP
CBL_PTK
0.6752
p.P2282S
ACH-000989
Colon/Colorectal Cancer
CCLE
NGQGIYSVKP
CBL_PTK
0.6752
p.P2282S
SNU-175
large_intestine
COSMIC
NGQGIYSVKP
CBL_PTK
0.6752
p.N2289S
TCGA-AX-A1CE
UCEC
TCGA
NGQGIYSVKP
CBL_PTK
0.1389
p.N2289S
DO42280
UCEC
ICGC
NGQGIYSVKP
CBL_PTK
0.1389
p.N2289S
SIDM00878
Breast Carcinoma
GDSC
NGQGIYSVKP
CBL_PTK
0.1389
p.N2289S
ACH-000930
Breast Cancer
CCLE
NGQGIYSVKP
CBL_PTK
0.1389
p.N2289S
HCC1569
breast
COSMIC
NGQGIYSVKP
CBL_PTK
0.1389
p.S2287L
DO225332
BRCA
ICGC
NGQGIYSVKP
CBL_PTK
0.1944
p.D2285N
DO233272
GACA
ICGC
NGQGIYSVKP
CBL_PTK
0.25
p.A2263S
DO229029
LICA
ICGC
NGQGIYSVKP
CBL_PTK
0.0556
p.P2282L
DO52365
LUSC
ICGC
NGQGIYSVKP
CBL_PTK
0.7582
p.P2282L
SIDM00525
Osteosarcoma
GDSC
NGQGIYSVKP
CBL_PTK
0.7582
Drug responses associated with PDZD2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NGQGIYSVKP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O15018
PDZ domain-containing protein 2
CBL_PTK
2273:2282
NGQGIYSVKP
CBL
0.719
More...
