DegronMD

Uniprot ID: O15018

Source protein: PDZ domain-containing protein 2

Source gene: PDZD2

Class: DEG_SCF_FBW7_1

Location: 2451:2457

E3 ligase: FBXW7

DEGRON score: 0.987

ASA_SCORE: 91.7143

COIL: 0.9246

CONS_SCORE: 0.2713

DSS_SCORE: 0.6342

HELIX: 0.0391

FCONS_SCORE: 0.779

RIG_SCORE: 0.679

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K2463R	TCGA-56-8626	LUSC	TCGA	IPTPTMT	DEG_SCF_FBW7_1	0.2778
p.K2463R	DO45506	LUSC	ICGC	IPTPTMT	DEG_SCF_FBW7_1	0.2778
p.G2450R	TCGA-EE-A2GM	SKCM	TCGA	IPTPTMT	DEG_SCF_FBW7_1	0.3056
p.G2450R	DO37555	SKCM	ICGC	IPTPTMT	DEG_SCF_FBW7_1	0.3056
p.M2456I	TCGA-EW-A1PH	BRCA	TCGA	IPTPTMT	DEG_SCF_FBW7_1	0.6507
p.M2456I	DO2551	BRCA	ICGC	IPTPTMT	DEG_SCF_FBW7_1	0.6507
p.T2457S	DO49439	PACA	ICGC	IPTPTMT	DEG_SCF_FBW7_1	0.6005
p.T2453I	SIDM00454	Rhabdomyosarcoma	GDSC	IPTPTMT	DEG_SCF_FBW7_1	0.8189
p.T2453I	ACH-000689	Sarcoma	CCLE	IPTPTMT	DEG_SCF_FBW7_1	0.8189
p.T2453I	RH-18	soft_tissue	COSMIC	IPTPTMT	DEG_SCF_FBW7_1	0.8189
p.P2461S	SIDM00177	Melanoma	GDSC	IPTPTMT	DEG_SCF_FBW7_1	0.2222
p.P2461S	ACH-002338	Skin Cancer	CCLE	IPTPTMT	DEG_SCF_FBW7_1	0.2222
p.P2461S	ACH-002510	Skin Cancer	CCLE	IPTPTMT	DEG_SCF_FBW7_1	0.2222
p.L2458V	SIDM00271	Gastric Carcinoma	GDSC	IPTPTMT	DEG_SCF_FBW7_1	0.3056
p.L2458V	ACH-000351	Gastric Cancer	CCLE	IPTPTMT	DEG_SCF_FBW7_1	0.3056
p.L2458V	MKN1	stomach	COSMIC	IPTPTMT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SCF_FBW7_1	2451:2457	IPTPTMT	FBXW7	0.987	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons