DegronMD

Uniprot ID: O15018

Source protein: PDZ domain-containing protein 2

Source gene: PDZD2

Class: DEG_APCC_DBOX_1

Location: 2264:2272

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9578

ASA_SCORE: 76.5

COIL: 0.8486

CONS_SCORE: 0.3118

DSS_SCORE: 0.488

HELIX: 0.0644

FCONS_SCORE: 1.0277

RIG_SCORE: 0.6499

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2269L	TCGA-EB-A553	SKCM	TCGA	SRGGLPSLA	DEG_APCC_DBOX_1	0.6471
p.P2269L	DO47329	SKCM	ICGC	SRGGLPSLA	DEG_APCC_DBOX_1	0.6471
p.A2263S	DO229029	LICA	ICGC	SRGGLPSLA	DEG_APCC_DBOX_1	0.3056
p.R2265T	DO231201	LUSC	ICGC	SRGGLPSLA	DEG_APCC_DBOX_1	0.7876
p.S2264F	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	SRGGLPSLA	DEG_APCC_DBOX_1	0.6871
p.S2264F	ACH-000873	Esophageal Cancer	CCLE	SRGGLPSLA	DEG_APCC_DBOX_1	0.6871
p.S2264F	KYSE-270	oesophagus	COSMIC	SRGGLPSLA	DEG_APCC_DBOX_1	0.6871

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_APCC_DBOX_1	2264:2272	SRGGLPSLA	APC,CDC20,FZR1	0.9578	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons