DegronMD

Uniprot ID: O15018

Source protein: PDZ domain-containing protein 2

Source gene: PDZD2

Class: DEG_SCF_FBW7_2

Location: 197:204

E3 ligase: FBXW7

DEGRON score: 0.9969

ASA_SCORE: 80.9125

COIL: 0.8525

CONS_SCORE: 0.3959

DSS_SCORE: 0.6771

HELIX: 0.0639

FCONS_SCORE: 1.1567

RIG_SCORE: 0.643

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A210V	TCGA-AG-A002	READ	TCGA	PGETPTLE	DEG_SCF_FBW7_2	0.1667
p.A210V	TCGA-BB-7870	HNSC	TCGA	PGETPTLE	DEG_SCF_FBW7_2	0.1667
p.A210V	TCGA-HU-A4H8	STAD	TCGA	PGETPTLE	DEG_SCF_FBW7_2	0.1667
p.A210V	DO14378	HNSC	ICGC	PGETPTLE	DEG_SCF_FBW7_2	0.1667
p.A210V	DO47869	STAD	ICGC	PGETPTLE	DEG_SCF_FBW7_2	0.1667
p.A210V	SIDM01030	Esophageal Squamous Cell Carcinoma	GDSC	PGETPTLE	DEG_SCF_FBW7_2	0.1667
p.A210V	ACH-000693	Esophageal Cancer	CCLE	PGETPTLE	DEG_SCF_FBW7_2	0.1667
p.A210V	KYSE-180	oesophagus	COSMIC	PGETPTLE	DEG_SCF_FBW7_2	0.1667
p.G213R	TCGA-D3-A8GQ	SKCM	TCGA	PGETPTLE	DEG_SCF_FBW7_2	0.0833
p.G213R	DO51246	SKCM	ICGC	PGETPTLE	DEG_SCF_FBW7_2	0.0833
p.R208Q	TCGA-LN-A9FP	ESCA	TCGA	PGETPTLE	DEG_SCF_FBW7_2	0.2222
p.R208Q	SIDM00545	Melanoma	GDSC	PGETPTLE	DEG_SCF_FBW7_2	0.2222
p.T209A	DO227614	COCA	ICGC	PGETPTLE	DEG_SCF_FBW7_2	0.6389
p.G189V	DO229006	LICA	ICGC	PGETPTLE	DEG_SCF_FBW7_2	0.1111
p.Y187C	SIDM00722	Mesothelioma	GDSC	PGETPTLE	DEG_SCF_FBW7_2	0.0556
p.S191C	SIDM01611	Endometrial Carcinoma	GDSC	PGETPTLE	DEG_SCF_FBW7_2	0.1667
p.S191C	ACH-000996	Endometrial/Uterine Cancer	CCLE	PGETPTLE	DEG_SCF_FBW7_2	0.1667
p.T202N	SIDM01611	Endometrial Carcinoma	GDSC	PGETPTLE	DEG_SCF_FBW7_2	0.5944
p.T202N	ACH-000996	Endometrial/Uterine Cancer	CCLE	PGETPTLE	DEG_SCF_FBW7_2	0.5944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SCF_FBW7_2	197:204	PGETPTLE	FBXW7	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons