DegronMD

Uniprot ID: O15018

Source protein: PDZ domain-containing protein 2

Source gene: PDZD2

Class: DEG_SPOP_SBC_1

Location: 2252:2256

E3 ligase: SPOP

DEGRON score: 0.9947

ASA_SCORE: 79.46

COIL: 0.8858

CONS_SCORE: 0.3835

DSS_SCORE: 0.6113

HELIX: 0.0296

FCONS_SCORE: 1.1542

RIG_SCORE: 0.6868

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2247Q	DO228483	BRCA	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1944
p.R2247Q	DO229003	COCA	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1944
p.R2247Q	DO229005	COCA	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1944
p.R2247Q	DO230525	LUSC	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1944
p.R2247Q	DO230554	LUSC	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1944
p.K2262N	DO230312	COCA	ICGC	PVTSS	DEG_SPOP_SBC_1	0.2778
p.A2263S	DO229029	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1389
p.R2245C	DO229062	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1389
p.V2253A	SIDM00340	Plasma Cell Myeloma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.5825
p.V2253A	SIDM00437	Acute Myeloid Leukemia	GDSC	PVTSS	DEG_SPOP_SBC_1	0.5825
p.V2253A	SIDM00487	Colorectal Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.5825
p.V2253A	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.5825
p.V2253A	SIDM00160	Biliary Tract Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.5825
p.V2253A	SIDM01776	Plasma Cell Myeloma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.5825
p.V2253A	SIDM01446	Glioblastoma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.5825
p.V2253A	SIDM01587	Bladder Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.5825
p.K2262R	SIDM01045	Endometrial Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.2778
p.K2262R	ACH-000978	Endometrial/Uterine Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	0.2778
p.K2262R	EN	endometrium	COSMIC	PVTSS	DEG_SPOP_SBC_1	0.2778
p.G2244V	SIDM00124	Kidney Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.1111
p.G2244V	ACH-000555	Kidney Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	0.1111
p.G2244V	A498	kidney	COSMIC	PVTSS	DEG_SPOP_SBC_1	0.1111
p.R2245H	ACH-001441	Eye Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	0.1389
p.R2245H	ACH-001559	Lung Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_SPOP_SBC_1	679:683	PVTSS	SPOP	0.7433	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2252:2256	PVTSS	SPOP	0.9947	More...
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	264:268	PVTSS	SPOP	0.9888	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1387:1391	PVTSS	SPOP	0.9755	More...
Q01543	Friend leukemia integration 1 transcription factor	DEG_SPOP_SBC_1	409:413	PVTSS	SPOP	0.9612	More...
Q12948	Forkhead box protein C1	DEG_SPOP_SBC_1	435:439	PVTSS	SPOP	0.9931	More...
Q13029	PR domain zinc finger protein 2	DEG_SPOP_SBC_1	727:731	PVTSS	SPOP	0.9999	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3945:3949	PVTSS	SPOP	0.9405	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_SPOP_SBC_1	372:376	PVTSS	SPOP	0.9626	More...
Q8NHV4	Protein NEDD1	DEG_SPOP_SBC_1	449:453	PVTSS	SPOP	0.9326	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	479:483	PVTSS	SPOP	0.9957	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5089:5093	PVTSS	SPOP	0.9713	More...
Q9H4E7	Differentially expressed in FDCP 6 homolog	DEG_SPOP_SBC_1	561:565	PVTSS	SPOP	0.9921	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	508:512	PVTSS	SPOP	0.9914	More...
Q9Y253	DNA polymerase eta	DEG_SPOP_SBC_1	455:459	PVTSS	SPOP	0.7281	More...
Q9Y458	T-box transcription factor TBX22	DEG_SPOP_SBC_1	324:328	PVTSS	SPOP	0.753	More...
Q2VYF4	LETM1 domain-containing protein LETM2, mitochondrial	DEG_SPOP_SBC_1	446:450	PVTSS	SPOP	0.9775	More...
Q8ND82	Zinc finger protein 280C	DEG_SPOP_SBC_1	211:215	PVTSS	SPOP	0.805	More...
Q9BZI1	Iroquois-class homeodomain protein IRX-2	DEG_SPOP_SBC_1	282:286	PVTSS	SPOP	0.9926	More...
Q3LI83	Keratin-associated protein 24-1	DEG_SPOP_SBC_1	27:31	PVTSS	SPOP	0.9114	More...
Q2M243	Coiled-coil domain-containing protein 27	DEG_SPOP_SBC_1	211:215	PVTSS	SPOP	0.6822	More...
Q8NCT3	Uncharacterized protein KIAA0895	DEG_SPOP_SBC_1	157:161	PVTSS	SPOP	0.9394	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTSS

Degron related mutations and impact score

Drug responses associated with PDZD2 mutations

All proteins holding degron of PVTSS