DegronMD - Q9BZI1(IRX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G290S	TCGA-60-2716	LUSC	TCGA	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.2222
p.G290S	DO27184	LUSC	ICGC	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.2222
p.E218D	TCGA-85-7843	LUSC	TCGA	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.2778
p.E218D	DO26500	LUSC	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.2778
p.S214L	TCGA-93-8067	LUAD	TCGA	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.1667
p.S214L	DO25113	LUAD	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.1667
p.S214L	DO47863	STAD	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.1667
p.E235K	TCGA-98-8021	LUSC	TCGA	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0556
p.E235K	DO27468	LUSC	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0556
p.S233L	TCGA-BF-A3DM	SKCM	TCGA	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation blocking phosphorylation signal	0.5556
p.S233L	TCGA-W3-AA1O	SKCM	TCGA	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation blocking phosphorylation signal	0.5556
p.S233L	DO48667	SKCM	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation blocking phosphorylation signal	0.5556
p.S233L	DO51274	SKCM	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation blocking phosphorylation signal	0.5556
p.S233L	SIDM01113	Other Sarcomas	GDSC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation blocking phosphorylation signal	0.5556
p.S233L	ACH-000939	Sarcoma	CCLE	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation blocking phosphorylation signal	0.5556
p.S233L	SK-UT-1	soft tissue	COSMIC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation blocking phosphorylation signal	0.5556
p.G210S	TCGA-BR-7715	STAD	TCGA	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0556
p.G210S	DO38679	STAD	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0556
p.T211M	TCGA-BR-8078	STAD	TCGA	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0833
p.T211M	DO38288	STAD	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0833
p.A278V	TCGA-IB-7651	PAAD	TCGA	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.2222
p.A278V	DO46657	PAAD	ICGC	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.2222
p.G276C	TCGA-L9-A7SV	LUAD	TCGA	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1667
p.G276C	DO49875	LUAD	ICGC	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1667
p.P287S	TCGA-QB-A6FS	SKCM	TCGA	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.P287S	DO48654	SKCM	ICGC	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.H223N	DO229019	LICA	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation altering degron motif	0.7423
p.T213N	DO229015	LICA	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.1389
p.T211K	DO229038	LICA	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0833
p.T211K	DO229045	LICA	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0833
p.G276S	DO50737	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1667
p.D225E	DO45299	LIRI	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation altering degron motif	0.5647
p.G210D	DO222696	MELA	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.0556
p.D225Y	DO50735	ORCA	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation altering degron motif	0.7325
p.D225Y	DO229216	THCA	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation altering degron motif	0.7325
p.K281T	DO33432	PACA	ICGC	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.3056
p.D229E	DO36556	READ	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.2222
p.L277Q	DO229272	THCA	ICGC	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1944
p.P282S	DO229216	THCA	ICGC	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.6752
p.T228K	DO229540	UTCA	ICGC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.25
p.S285L	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7667
p.S285L	SIDM00986	Head and Neck Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7667
p.S285L	ACH-000548	Head and Neck Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7667
p.S285L	ACH-000892	Lung Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7667
p.S285L	NCI-H1563	lung	COSMIC	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7667
p.S285L	BHY	upper aerodigestive tract	COSMIC	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7667
p.P279L	SIDM00537	Colorectal Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.25
p.P279L	GP5d	large intestine	COSMIC	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.25
p.G219W	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	ISLHVD	LIG_APCC_ABBA_1	220:225	Mutation rewiring degron network	0.3056
p.A293E	ACH-000943	Colon/Colorectal Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IRX2

UniProt ID: Q9BZI1

Entrez ID: 153572

Protein name: Iroquois-class homeodomain protein IRX-2 (Homeodomain protein IRXA2) (Iroquois homeobox protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IRX2 in