DegronMD

Uniprot ID: Q9BZI1

Source protein: Iroquois-class homeodomain protein IRX-2

Source gene: IRX2

Class: LIG_APCC_ABBA_1

Location: 220:225

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7909

ASA_SCORE: 85.7833

COIL: 0.788

CONS_SCORE: 0.3821

DSS_SCORE: 0.5887

HELIX: 0.1427

FCONS_SCORE: 0.8962

RIG_SCORE: 0.7011

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E218D	TCGA-85-7843	LUSC	TCGA	ISLHVD	LIG_APCC_ABBA_1	0.2778
p.E218D	DO26500	LUSC	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.2778
p.S214L	TCGA-93-8067	LUAD	TCGA	ISLHVD	LIG_APCC_ABBA_1	0.1667
p.S214L	DO25113	LUAD	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.1667
p.S214L	DO47863	STAD	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.1667
p.E235K	TCGA-98-8021	LUSC	TCGA	ISLHVD	LIG_APCC_ABBA_1	0.0556
p.E235K	DO27468	LUSC	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.0556
p.S233L	TCGA-BF-A3DM	SKCM	TCGA	ISLHVD	LIG_APCC_ABBA_1	0.5556
p.S233L	TCGA-W3-AA1O	SKCM	TCGA	ISLHVD	LIG_APCC_ABBA_1	0.5556
p.S233L	DO48667	SKCM	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.5556
p.S233L	DO51274	SKCM	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.5556
p.S233L	SIDM01113	Other Sarcomas	GDSC	ISLHVD	LIG_APCC_ABBA_1	0.5556
p.S233L	ACH-000939	Sarcoma	CCLE	ISLHVD	LIG_APCC_ABBA_1	0.5556
p.S233L	SK-UT-1	soft_tissue	COSMIC	ISLHVD	LIG_APCC_ABBA_1	0.5556
p.G210S	TCGA-BR-7715	STAD	TCGA	ISLHVD	LIG_APCC_ABBA_1	0.0556
p.G210S	DO38679	STAD	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.0556
p.T211M	TCGA-BR-8078	STAD	TCGA	ISLHVD	LIG_APCC_ABBA_1	0.0833
p.T211M	DO38288	STAD	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.0833
p.H223N	DO229019	LICA	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.7423
p.T213N	DO229015	LICA	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.1389
p.T211K	DO229038	LICA	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.0833
p.T211K	DO229045	LICA	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.0833
p.D225E	DO45299	LIRI	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.5647
p.G210D	DO222696	MELA	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.0556
p.D225Y	DO50735	ORCA	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.7325
p.D225Y	DO229216	THCA	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.7325
p.D229E	DO36556	READ	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.2222
p.T228K	DO229540	UTCA	ICGC	ISLHVD	LIG_APCC_ABBA_1	0.25
p.G219W	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	ISLHVD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZI1	Iroquois-class homeodomain protein IRX-2	LIG_APCC_ABBA_1	220:225	ISLHVD	APC,CDC20,FZR1	0.7909	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ISLHVD

Degron related mutations and impact score

Drug responses associated with IRX2 mutations

All proteins holding degron of ISLHVD