DegronMD

Uniprot ID: Q9BZI1

Source protein: Iroquois-class homeodomain protein IRX-2

Source gene: IRX2

Class: DEG_SPOP_SBC_1

Location: 282:286

E3 ligase: SPOP

DEGRON score: 0.9926

ASA_SCORE: 71

COIL: 0.9186

CONS_SCORE: 0.4086

DSS_SCORE: 0.7553

HELIX: 0.0322

FCONS_SCORE: 1.0516

RIG_SCORE: 0.5998

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G290S	TCGA-60-2716	LUSC	TCGA	PVTSS	DEG_SPOP_SBC_1	0.2222
p.G290S	DO27184	LUSC	ICGC	PVTSS	DEG_SPOP_SBC_1	0.2222
p.A278V	TCGA-IB-7651	PAAD	TCGA	PVTSS	DEG_SPOP_SBC_1	0.2222
p.A278V	DO46657	PAAD	ICGC	PVTSS	DEG_SPOP_SBC_1	0.2222
p.G276C	TCGA-L9-A7SV	LUAD	TCGA	PVTSS	DEG_SPOP_SBC_1	0.1667
p.G276C	DO49875	LUAD	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1667
p.P287S	TCGA-QB-A6FS	SKCM	TCGA	PVTSS	DEG_SPOP_SBC_1	0.3056
p.P287S	DO48654	SKCM	ICGC	PVTSS	DEG_SPOP_SBC_1	0.3056
p.G276S	DO50737	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1667
p.K281T	DO33432	PACA	ICGC	PVTSS	DEG_SPOP_SBC_1	0.3056
p.L277Q	DO229272	THCA	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1944
p.P282S	DO229216	THCA	ICGC	PVTSS	DEG_SPOP_SBC_1	0.6752
p.S285L	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.7667
p.S285L	SIDM00986	Head and Neck Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.7667
p.S285L	ACH-000548	Head and Neck Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	0.7667
p.S285L	ACH-000892	Lung Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	0.7667
p.S285L	NCI-H1563	lung	COSMIC	PVTSS	DEG_SPOP_SBC_1	0.7667
p.S285L	BHY	upper_aerodigestive_tract	COSMIC	PVTSS	DEG_SPOP_SBC_1	0.7667
p.P279L	SIDM00537	Colorectal Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.25
p.P279L	GP5d	large_intestine	COSMIC	PVTSS	DEG_SPOP_SBC_1	0.25
p.A293E	ACH-000943	Colon/Colorectal Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_SPOP_SBC_1	679:683	PVTSS	SPOP	0.7433	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2252:2256	PVTSS	SPOP	0.9947	More...
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	264:268	PVTSS	SPOP	0.9888	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1387:1391	PVTSS	SPOP	0.9755	More...
Q01543	Friend leukemia integration 1 transcription factor	DEG_SPOP_SBC_1	409:413	PVTSS	SPOP	0.9612	More...
Q12948	Forkhead box protein C1	DEG_SPOP_SBC_1	435:439	PVTSS	SPOP	0.9931	More...
Q13029	PR domain zinc finger protein 2	DEG_SPOP_SBC_1	727:731	PVTSS	SPOP	0.9999	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3945:3949	PVTSS	SPOP	0.9405	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_SPOP_SBC_1	372:376	PVTSS	SPOP	0.9626	More...
Q8NHV4	Protein NEDD1	DEG_SPOP_SBC_1	449:453	PVTSS	SPOP	0.9326	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	479:483	PVTSS	SPOP	0.9957	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5089:5093	PVTSS	SPOP	0.9713	More...
Q9H4E7	Differentially expressed in FDCP 6 homolog	DEG_SPOP_SBC_1	561:565	PVTSS	SPOP	0.9921	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	508:512	PVTSS	SPOP	0.9914	More...
Q9Y253	DNA polymerase eta	DEG_SPOP_SBC_1	455:459	PVTSS	SPOP	0.7281	More...
Q9Y458	T-box transcription factor TBX22	DEG_SPOP_SBC_1	324:328	PVTSS	SPOP	0.753	More...
Q2VYF4	LETM1 domain-containing protein LETM2, mitochondrial	DEG_SPOP_SBC_1	446:450	PVTSS	SPOP	0.9775	More...
Q8ND82	Zinc finger protein 280C	DEG_SPOP_SBC_1	211:215	PVTSS	SPOP	0.805	More...
Q9BZI1	Iroquois-class homeodomain protein IRX-2	DEG_SPOP_SBC_1	282:286	PVTSS	SPOP	0.9926	More...
Q3LI83	Keratin-associated protein 24-1	DEG_SPOP_SBC_1	27:31	PVTSS	SPOP	0.9114	More...
Q2M243	Coiled-coil domain-containing protein 27	DEG_SPOP_SBC_1	211:215	PVTSS	SPOP	0.6822	More...
Q8NCT3	Uncharacterized protein KIAA0895	DEG_SPOP_SBC_1	157:161	PVTSS	SPOP	0.9394	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTSS

Degron related mutations and impact score

Drug responses associated with IRX2 mutations

All proteins holding degron of PVTSS