DegronMD

Uniprot ID: Q3LI83

Source protein: Keratin-associated protein 24-1

Source gene: KRTAP24-1

Class: DEG_SPOP_SBC_1

Location: 27:31

E3 ligase: SPOP

DEGRON score: 0.9114

ASA_SCORE: 78.1

COIL: 0.8438

CONS_SCORE: 0.8944

DSS_SCORE: 0.1755

HELIX: 0.0254

FCONS_SCORE: 1.189

RIG_SCORE: 0.8217

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S31Y	TCGA-AN-A046	BRCA	TCGA	PVTSS	DEG_SPOP_SBC_1	0.712
p.S31Y	TCGA-EO-A3B0	UCEC	TCGA	PVTSS	DEG_SPOP_SBC_1	0.712
p.S31Y	DO1285	BRCA	ICGC	PVTSS	DEG_SPOP_SBC_1	0.712
p.S31Y	DO219773	UCEC	ICGC	PVTSS	DEG_SPOP_SBC_1	0.712
p.S30P	DO229237	LMS	ICGC	PVTSS	DEG_SPOP_SBC_1	0.6752
p.V28L	DO50439	ESAD	ICGC	PVTSS	DEG_SPOP_SBC_1	0.5654
p.C24S	TCGA-56-8626	LUSC	TCGA	PVTSS	DEG_SPOP_SBC_1	0.25
p.C24S	DO45506	LUSC	ICGC	PVTSS	DEG_SPOP_SBC_1	0.25
p.C24W	SIDM00118	Colorectal Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.25
p.C24W	ACH-001081	Colon/Colorectal Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	0.25
p.C24W	HCC2998	large_intestine	COSMIC	PVTSS	DEG_SPOP_SBC_1	0.25
p.S35G	SIDM01146	Gastric Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.2222
p.S35G	ACH-000932	Gastric Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	0.2222
p.S35G	NCI-SNU-1	stomach	COSMIC	PVTSS	DEG_SPOP_SBC_1	0.2222
p.S36P	DO234258	ESAD	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1944
p.R21I	TCGA-AG-3892	READ	TCGA	PVTSS	DEG_SPOP_SBC_1	0.1667
p.R21I	DO36394	READ	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1667
p.R21S	DO231598	LINC	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1667
p.R21S	DO231553	LINC	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1667
p.T17S	TCGA-69-7979	LUAD	TCGA	PVTSS	DEG_SPOP_SBC_1	0.0556
p.T17S	DO23874	LUAD	ICGC	PVTSS	DEG_SPOP_SBC_1	0.0556
p.T17I	TCGA-BH-A0DG	BRCA	TCGA	PVTSS	DEG_SPOP_SBC_1	0.0556
p.T17I	DO1257	BRCA	ICGC	PVTSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 23 of 23 entries

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Drug responses associated with KRTAP24-1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PVTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	479:483	PVTSS	SPOP	0.9957	More...
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	264:268	PVTSS	SPOP	0.9888	More...
Q2M243	Coiled-coil domain-containing protein 27	DEG_SPOP_SBC_1	211:215	PVTSS	SPOP	0.6822	More...
Q9H4E7	Differentially expressed in FDCP 6 homolog	DEG_SPOP_SBC_1	561:565	PVTSS	SPOP	0.9921	More...
Q9Y253	DNA polymerase eta	DEG_SPOP_SBC_1	455:459	PVTSS	SPOP	0.7281	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_SPOP_SBC_1	372:376	PVTSS	SPOP	0.9626	More...
Q12948	Forkhead box protein C1	DEG_SPOP_SBC_1	435:439	PVTSS	SPOP	0.9931	More...
Q01543	Friend leukemia integration 1 transcription factor	DEG_SPOP_SBC_1	409:413	PVTSS	SPOP	0.9612	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	508:512	PVTSS	SPOP	0.9914	More...
Q9BZI1	Iroquois-class homeodomain protein IRX-2	DEG_SPOP_SBC_1	282:286	PVTSS	SPOP	0.9926	More...
Q3LI83	Keratin-associated protein 24-1	DEG_SPOP_SBC_1	27:31	PVTSS	SPOP	0.9114	More...
Q2VYF4	LETM1 domain-containing protein LETM2, mitochondrial	DEG_SPOP_SBC_1	446:450	PVTSS	SPOP	0.9775	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5089:5093	PVTSS	SPOP	0.9713	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3945:3949	PVTSS	SPOP	0.9405	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1387:1391	PVTSS	SPOP	0.9755	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2252:2256	PVTSS	SPOP	0.9947	More...
Q13029	PR domain zinc finger protein 2	DEG_SPOP_SBC_1	727:731	PVTSS	SPOP	0.9999	More...
Q8NHV4	Protein NEDD1	DEG_SPOP_SBC_1	449:453	PVTSS	SPOP	0.9326	More...
Q9Y458	T-box transcription factor TBX22	DEG_SPOP_SBC_1	324:328	PVTSS	SPOP	0.753	More...
A0AVK6	Transcription factor E2F8	DEG_SPOP_SBC_1	679:683	PVTSS	SPOP	0.7433	More...
Q8NCT3	Uncharacterized protein KIAA0895	DEG_SPOP_SBC_1	157:161	PVTSS	SPOP	0.9394	More...
Q8ND82	Zinc finger protein 280C	DEG_SPOP_SBC_1	211:215	PVTSS	SPOP	0.805	More...

Showing 1 to 22 of 22 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTSS

Degron related mutations and impact score

Drug responses associated with KRTAP24-1 mutations

All proteins holding degron of PVTSS