DegronMD

Uniprot ID: Q9Y253

Source protein: DNA polymerase eta

Source gene: POLH

Class: DEG_SPOP_SBC_1

Location: 455:459

E3 ligase: SPOP

DEGRON score: 0.7281

ASA_SCORE: 83.7

COIL: 0.894

CONS_SCORE: 0.2232

DSS_SCORE: 0.6049

HELIX: 0.0836

FCONS_SCORE: 0.9547

RIG_SCORE: 0.6673

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S450Y	TCGA-AG-A002	READ	TCGA	PVTSS	DEG_SPOP_SBC_1	0.1944
p.S450Y	SIDM00534	Colorectal Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.1944
p.S450Y	ACH-000986	Colon/Colorectal Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	0.1944
p.S450Y	HT-115	large_intestine	COSMIC	PVTSS	DEG_SPOP_SBC_1	0.1944
p.P448L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PVTSS	DEG_SPOP_SBC_1	0.1389
p.P448L	ACH-002256	Leukemia	CCLE	PVTSS	DEG_SPOP_SBC_1	0.1389
p.P448L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PVTSS	DEG_SPOP_SBC_1	0.1389
p.P455S	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PVTSS	DEG_SPOP_SBC_1	0.6752
p.P455S	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PVTSS	DEG_SPOP_SBC_1	0.6752
p.A469V	SIDM00562	Breast Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.0556
p.A469V	MRK-nu-1	breast	COSMIC	PVTSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0AVK6	Transcription factor E2F8	DEG_SPOP_SBC_1	679:683	PVTSS	SPOP	0.7433	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2252:2256	PVTSS	SPOP	0.9947	More...
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	264:268	PVTSS	SPOP	0.9888	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1387:1391	PVTSS	SPOP	0.9755	More...
Q01543	Friend leukemia integration 1 transcription factor	DEG_SPOP_SBC_1	409:413	PVTSS	SPOP	0.9612	More...
Q12948	Forkhead box protein C1	DEG_SPOP_SBC_1	435:439	PVTSS	SPOP	0.9931	More...
Q13029	PR domain zinc finger protein 2	DEG_SPOP_SBC_1	727:731	PVTSS	SPOP	0.9999	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3945:3949	PVTSS	SPOP	0.9405	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_SPOP_SBC_1	372:376	PVTSS	SPOP	0.9626	More...
Q8NHV4	Protein NEDD1	DEG_SPOP_SBC_1	449:453	PVTSS	SPOP	0.9326	More...
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	479:483	PVTSS	SPOP	0.9957	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5089:5093	PVTSS	SPOP	0.9713	More...
Q9H4E7	Differentially expressed in FDCP 6 homolog	DEG_SPOP_SBC_1	561:565	PVTSS	SPOP	0.9921	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	508:512	PVTSS	SPOP	0.9914	More...
Q9Y253	DNA polymerase eta	DEG_SPOP_SBC_1	455:459	PVTSS	SPOP	0.7281	More...
Q9Y458	T-box transcription factor TBX22	DEG_SPOP_SBC_1	324:328	PVTSS	SPOP	0.753	More...
Q2VYF4	LETM1 domain-containing protein LETM2, mitochondrial	DEG_SPOP_SBC_1	446:450	PVTSS	SPOP	0.9775	More...
Q8ND82	Zinc finger protein 280C	DEG_SPOP_SBC_1	211:215	PVTSS	SPOP	0.805	More...
Q9BZI1	Iroquois-class homeodomain protein IRX-2	DEG_SPOP_SBC_1	282:286	PVTSS	SPOP	0.9926	More...
Q3LI83	Keratin-associated protein 24-1	DEG_SPOP_SBC_1	27:31	PVTSS	SPOP	0.9114	More...
Q2M243	Coiled-coil domain-containing protein 27	DEG_SPOP_SBC_1	211:215	PVTSS	SPOP	0.6822	More...
Q8NCT3	Uncharacterized protein KIAA0895	DEG_SPOP_SBC_1	157:161	PVTSS	SPOP	0.9394	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTSS

Degron related mutations and impact score

Drug responses associated with POLH mutations

All proteins holding degron of PVTSS