DegronMD - Q9Y458(TBX22)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W300L	TCGA-4B-A93V	LUAD	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.1944
p.W300L	TCGA-D3-A2JP	SKCM	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.1944
p.W300L	DO218926	LUAD	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.1944
p.W300L	DO47407	SKCM	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.1944
p.V325L	TCGA-50-6593	LUAD	TCGA	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation altering degron motif	0.5654
p.V325L	DO24100	LUAD	ICGC	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation altering degron motif	0.5654
p.T284N	TCGA-55-8511	LUAD	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.25
p.T284N	DO24940	LUAD	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.25
p.S319N	TCGA-66-2771	LUSC	TCGA	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.1944
p.S319N	DO26870	LUSC	ICGC	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.1944
p.G289D	TCGA-78-8662	LUAD	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation altering degron motif	0.6087
p.G289D	DO45346	LUAD	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation altering degron motif	0.6087
p.S83R	TCGA-92-7340	LUSC	TCGA	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.8538
p.S83R	DO26775	LUSC	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.8538
p.G318V	TCGA-98-8021	LUSC	TCGA	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.1667
p.G318V	DO27468	LUSC	ICGC	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.1667
p.G79S	TCGA-A6-2677	COAD	TCGA	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.6993
p.G79S	DO8288	COAD	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.6993
p.S69F	TCGA-AC-A2B8	BRCA	TCGA	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation blocking phosphorylation signal	0.5556
p.S69F	DO5884	BRCA	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation blocking phosphorylation signal	0.5556
p.R288G	TCGA-AP-A1DK	UCEC	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation altering degron motif	0.7568
p.R288G	DO42033	UCEC	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation altering degron motif	0.7568
p.R288M	TCGA-CN-6010	HNSC	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation altering degron motif	0.8632
p.R288M	DO14766	HNSC	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation altering degron motif	0.8632
p.S323F	TCGA-CN-6021	HNSC	TCGA	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.3056
p.S323F	DO15847	HNSC	ICGC	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.3056
p.L335F	TCGA-CN-6989	HNSC	TCGA	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.1389
p.L335F	DO14814	HNSC	ICGC	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.1389
p.F304L	TCGA-CV-6952	HNSC	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.0833
p.F304L	DO14240	HNSC	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.0833
p.R282K	TCGA-D9-A6EC	SKCM	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.1944
p.R282K	DO50291	SKCM	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.1944
p.S71Y	TCGA-E6-A1LX	UCEC	TCGA	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.1667
p.S71Y	DO41020	UCEC	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.1667
p.E296K	TCGA-E6-A1LX	UCEC	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.3056
p.E296K	DO41020	UCEC	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.3056
p.G293W	TCGA-EB-A299	SKCM	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation altering degron motif	0.6714
p.G293W	DO37794	SKCM	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation altering degron motif	0.6714
p.P334H	TCGA-EB-A431	SKCM	TCGA	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.1667
p.P334H	DO37671	SKCM	ICGC	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.1667
p.S333C	TCGA-EE-A2MC	SKCM	TCGA	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.1944
p.S333C	DO222426	MELA	ICGC	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.1944
p.S333C	DO37559	SKCM	ICGC	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.1944
p.G81S	TCGA-EY-A215	UCEC	TCGA	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.5882
p.G81S	DO42665	UCEC	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.5882
p.E296D	TCGA-G3-AAV6	LIHC	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.3056
p.E296D	DO52299	LIHC	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.3056
p.E296D	ACH-001608	Brain Cancer	CCLE	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.3056
p.P299L	TCGA-HU-A4G6	STAD	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.2222
p.P299L	DO47747	STAD	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.2222
p.D77N	TCGA-IN-A6RS	STAD	TCGA	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.6932
p.D77N	DO51743	STAD	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.6932
p.T305I	TCGA-K4-A3WV	BLCA	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.0556
p.T305I	DO683	BLCA	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.0556
p.V290A	TCGA-R6-A6L4	ESCA	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation altering degron motif	0.5825
p.T297N	TCGA-XF-A9T3	BLCA	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.2778
p.T297N	DO51922	BLCA	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.2778
p.E89D	DO222867	BTCA	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.1667
p.T297I	DO229361	BTCA	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.2778
p.L294I	DO233189	GACA	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation altering degron motif	0.6063
p.T68A	DO233709	GACA	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation blocking phosphorylation signal	0.5278
p.G81D	DO228405	LICA	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation altering degron motif	0.6087
p.G280R	DO222868	MELA	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.1389
p.P302T	DO229211	THCA	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.1389
p.F277L	SIDM00282	Colorectal Carcinoma	GDSC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.0556
p.F277L	ACH-000998	Colon/Colorectal Cancer	CCLE	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.0556
p.F277L	CW-2	large intestine	COSMIC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.0556
p.Q316R	SIDM00655	Other Solid Cancers	GDSC	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.1111
p.Q316R	ACH-001578	Embryonal Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.1111
p.Q316R	NCCIT	testis	COSMIC	PVTSS	DEG_SPOP_SBC_1	324:328	Mutation rewiring degron network	0.1111
p.G75C	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.2778
p.G75C	ACH-001498	Lymphoma	CCLE	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.2778
p.G75C	Farage	haematopoietic and lymphoid tissue	COSMIC	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.2778
p.R301M	SIDM00980	Gastric Carcinoma	GDSC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.1667
p.R301M	ACH-000948	Gastric Cancer	CCLE	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.1667
p.R301M	23132-87	stomach	COSMIC	NRGVLDGLL	DEG_APCC_DBOX_1	287:295	Mutation rewiring degron network	0.1667
p.S67L	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGYGNS	DEG_SCF_TRCP1_1	77:83	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBX22

UniProt ID: Q9Y458

Entrez ID: 50945

Protein name: T-box transcription factor TBX22 (T-box protein 22)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TBX22 in