DegronMD

Uniprot ID: Q9Y458

Source protein: T-box transcription factor TBX22

Source gene: TBX22

Class: DEG_APCC_DBOX_1

Location: 287:295

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8353

ASA_SCORE: 75.2889

COIL: 0.7591

CONS_SCORE: 0.4213

DSS_SCORE: 0.3367

HELIX: 0.1828

FCONS_SCORE: 0.8159

RIG_SCORE: 0.7872

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W300L	TCGA-4B-A93V	LUAD	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	0.1944
p.W300L	TCGA-D3-A2JP	SKCM	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	0.1944
p.W300L	DO218926	LUAD	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.1944
p.W300L	DO47407	SKCM	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.1944
p.T284N	TCGA-55-8511	LUAD	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	0.25
p.T284N	DO24940	LUAD	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.25
p.G289D	TCGA-78-8662	LUAD	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	0.6087
p.G289D	DO45346	LUAD	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.6087
p.R288G	TCGA-AP-A1DK	UCEC	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	0.7568
p.R288G	DO42033	UCEC	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.7568
p.R288M	TCGA-CN-6010	HNSC	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	0.8632
p.R288M	DO14766	HNSC	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.8632
p.F304L	TCGA-CV-6952	HNSC	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	0.0833
p.F304L	DO14240	HNSC	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.0833
p.R282K	TCGA-D9-A6EC	SKCM	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	0.1944
p.R282K	DO50291	SKCM	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.1944
p.E296K	TCGA-E6-A1LX	UCEC	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	0.3056
p.E296K	DO41020	UCEC	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.3056
p.G293W	TCGA-EB-A299	SKCM	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	0.6714
p.G293W	DO37794	SKCM	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.6714
p.E296D	TCGA-G3-AAV6	LIHC	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	0.3056
p.E296D	DO52299	LIHC	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.3056
p.E296D	ACH-001608	Brain Cancer	CCLE	NRGVLDGLL	DEG_APCC_DBOX_1	0.3056
p.P299L	TCGA-HU-A4G6	STAD	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	0.2222
p.P299L	DO47747	STAD	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.2222
p.T305I	TCGA-K4-A3WV	BLCA	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	0.0556
p.T305I	DO683	BLCA	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.0556
p.V290A	TCGA-R6-A6L4	ESCA	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	0.5825
p.T297N	TCGA-XF-A9T3	BLCA	TCGA	NRGVLDGLL	DEG_APCC_DBOX_1	0.2778
p.T297N	DO51922	BLCA	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.2778
p.T297I	DO229361	BTCA	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.2778
p.L294I	DO233189	GACA	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.6063
p.G280R	DO222868	MELA	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.1389
p.P302T	DO229211	THCA	ICGC	NRGVLDGLL	DEG_APCC_DBOX_1	0.1389
p.F277L	SIDM00282	Colorectal Carcinoma	GDSC	NRGVLDGLL	DEG_APCC_DBOX_1	0.0556
p.F277L	ACH-000998	Colon/Colorectal Cancer	CCLE	NRGVLDGLL	DEG_APCC_DBOX_1	0.0556
p.F277L	CW-2	large_intestine	COSMIC	NRGVLDGLL	DEG_APCC_DBOX_1	0.0556
p.R301M	SIDM00980	Gastric Carcinoma	GDSC	NRGVLDGLL	DEG_APCC_DBOX_1	0.1667
p.R301M	ACH-000948	Gastric Cancer	CCLE	NRGVLDGLL	DEG_APCC_DBOX_1	0.1667
p.R301M	23132-87	stomach	COSMIC	NRGVLDGLL	DEG_APCC_DBOX_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRGVLDGLL

Degron related mutations and impact score

Drug responses associated with TBX22 mutations

All proteins holding degron of NRGVLDGLL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y458	T-box transcription factor TBX22	DEG_APCC_DBOX_1	287:295	NRGVLDGLL	APC,CDC20,FZR1	0.8353	More...