DegronMD

Uniprot ID: Q9Y458

Source protein: T-box transcription factor TBX22

Source gene: TBX22

Class: DEG_SCF_TRCP1_1

Location: 77:83

E3 ligase: BTRC

DEGRON score: 0.9969

ASA_SCORE: 76.5714

COIL: 0.9123

CONS_SCORE: 0.3233

DSS_SCORE: 0.642

HELIX: 0.0619

FCONS_SCORE: 0.8975

RIG_SCORE: 0.536

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S83R	TCGA-92-7340	LUSC	TCGA	DSGYGNS	DEG_SCF_TRCP1_1	0.8538
p.S83R	DO26775	LUSC	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	0.8538
p.G79S	TCGA-A6-2677	COAD	TCGA	DSGYGNS	DEG_SCF_TRCP1_1	0.6993
p.G79S	DO8288	COAD	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	0.6993
p.S69F	TCGA-AC-A2B8	BRCA	TCGA	DSGYGNS	DEG_SCF_TRCP1_1	0.5556
p.S69F	DO5884	BRCA	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	0.5556
p.S71Y	TCGA-E6-A1LX	UCEC	TCGA	DSGYGNS	DEG_SCF_TRCP1_1	0.1667
p.S71Y	DO41020	UCEC	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	0.1667
p.G81S	TCGA-EY-A215	UCEC	TCGA	DSGYGNS	DEG_SCF_TRCP1_1	0.5882
p.G81S	DO42665	UCEC	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	0.5882
p.D77N	TCGA-IN-A6RS	STAD	TCGA	DSGYGNS	DEG_SCF_TRCP1_1	0.6932
p.D77N	DO51743	STAD	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	0.6932
p.E89D	DO222867	BTCA	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	0.1667
p.T68A	DO233709	GACA	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	0.5278
p.G81D	DO228405	LICA	ICGC	DSGYGNS	DEG_SCF_TRCP1_1	0.6087
p.G75C	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGYGNS	DEG_SCF_TRCP1_1	0.2778
p.G75C	ACH-001498	Lymphoma	CCLE	DSGYGNS	DEG_SCF_TRCP1_1	0.2778
p.G75C	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	DSGYGNS	DEG_SCF_TRCP1_1	0.2778
p.S67L	ACH-001061	Colon/Colorectal Cancer	CCLE	DSGYGNS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y458	T-box transcription factor TBX22	DEG_SCF_TRCP1_1	77:83	DSGYGNS	BTRC	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons