DegronMD - Q9H4E7(DEF6)

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GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P573T	TCGA-29-1696	OV	TCGA	PVTSS	DEG_SPOP_SBC_1	561:565	Mutation rewiring degron network	0.1111
p.P573T	DO30190	OV	ICGC	PVTSS	DEG_SPOP_SBC_1	561:565	Mutation rewiring degron network	0.1111
p.P561L	TCGA-BR-8487	STAD	TCGA	PVTSS	DEG_SPOP_SBC_1	561:565	Mutation altering degron motif	0.7582
p.P561L	DO47867	STAD	ICGC	PVTSS	DEG_SPOP_SBC_1	561:565	Mutation altering degron motif	0.7582
p.P561S	TCGA-BT-A3PJ	BLCA	TCGA	PVTSS	DEG_SPOP_SBC_1	561:565	Mutation altering degron motif	0.6752
p.P561S	DO44097	BLCA	ICGC	PVTSS	DEG_SPOP_SBC_1	561:565	Mutation altering degron motif	0.6752
p.R560H	TCGA-EK-A2GZ	CESC	TCGA	PVTSS	DEG_SPOP_SBC_1	561:565	Mutation rewiring degron network	0.3056
p.R560H	DO49937	CESC	ICGC	PVTSS	DEG_SPOP_SBC_1	561:565	Mutation rewiring degron network	0.3056
p.R560H	ACH-001970	Metastasis	CCLE	PVTSS	DEG_SPOP_SBC_1	561:565	Mutation rewiring degron network	0.3056
p.L574V	TCGA-VS-A958	CESC	TCGA	PVTSS	DEG_SPOP_SBC_1	561:565	Mutation rewiring degron network	0.0833
p.L574V	DO51639	CESC	ICGC	PVTSS	DEG_SPOP_SBC_1	561:565	Mutation rewiring degron network	0.0833
p.D558Y	DO229027	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	561:565	Mutation rewiring degron network	0.25
p.E555D	DO229031	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	561:565	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons