DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 3945:3949

E3 ligase: SPOP

DEGRON score: 0.9405

ASA_SCORE: 83.76

COIL: 0.854

CONS_SCORE: 0.5236

DSS_SCORE: 0.3612

HELIX: 0.0184

FCONS_SCORE: 1

RIG_SCORE: 0.7456

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3949Y	TCGA-E6-A1LX	UCEC	TCGA	PVTSS	DEG_SPOP_SBC_1	0.712
p.S3949Y	DO41020	UCEC	ICGC	PVTSS	DEG_SPOP_SBC_1	0.712
p.T3947N	TCGA-44-6147	LUAD	TCGA	PVTSS	DEG_SPOP_SBC_1	0.7055
p.T3947N	DO24740	LUAD	ICGC	PVTSS	DEG_SPOP_SBC_1	0.7055
p.V3946I	DO233731	GACA	ICGC	PVTSS	DEG_SPOP_SBC_1	0.5965
p.A3951V	ACH-001786	Colon/Colorectal Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	0.2778
p.D3952Y	DO229027	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	0.25
p.A3956E	TCGA-39-5030	LUSC	TCGA	PVTSS	DEG_SPOP_SBC_1	0.1389
p.A3956E	DO7418	CLLE	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1389
p.A3956E	DO27176	LUSC	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1389
p.T3938A	DO228732	GACA	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1389
p.T3938A	DO42673	UCEC	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1389
p.T3957I	TCGA-AA-A01I	COAD	TCGA	PVTSS	DEG_SPOP_SBC_1	0.1111
p.T3957I	DO10510	COAD	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1111
p.T3937A	TCGA-VQ-A8PX	STAD	TCGA	PVTSS	DEG_SPOP_SBC_1	0.1111
p.T3937A	DO51778	STAD	ICGC	PVTSS	DEG_SPOP_SBC_1	0.1111
p.P3935L	TCGA-B5-A11E	UCEC	TCGA	PVTSS	DEG_SPOP_SBC_1	0.0556
p.P3935L	DO23250	LINC	ICGC	PVTSS	DEG_SPOP_SBC_1	0.0556
p.P3935L	DO41644	UCEC	ICGC	PVTSS	DEG_SPOP_SBC_1	0.0556
p.G3959A	SIDM01449	Pancreatic Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	0.0556
p.G3959A	ACH-000517	Pancreatic Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 21 of 21 entries

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Drug responses associated with MUC17 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PVTSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WWM7	Ataxin-2-like protein	DEG_SPOP_SBC_1	479:483	PVTSS	SPOP	0.9957	More...
O43670	BUB3-interacting and GLEBS motif-containing protein ZNF207	DEG_SPOP_SBC_1	264:268	PVTSS	SPOP	0.9888	More...
Q2M243	Coiled-coil domain-containing protein 27	DEG_SPOP_SBC_1	211:215	PVTSS	SPOP	0.6822	More...
Q9H4E7	Differentially expressed in FDCP 6 homolog	DEG_SPOP_SBC_1	561:565	PVTSS	SPOP	0.9921	More...
Q9Y253	DNA polymerase eta	DEG_SPOP_SBC_1	455:459	PVTSS	SPOP	0.7281	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_SPOP_SBC_1	372:376	PVTSS	SPOP	0.9626	More...
Q12948	Forkhead box protein C1	DEG_SPOP_SBC_1	435:439	PVTSS	SPOP	0.9931	More...
Q01543	Friend leukemia integration 1 transcription factor	DEG_SPOP_SBC_1	409:413	PVTSS	SPOP	0.9612	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	508:512	PVTSS	SPOP	0.9914	More...
Q9BZI1	Iroquois-class homeodomain protein IRX-2	DEG_SPOP_SBC_1	282:286	PVTSS	SPOP	0.9926	More...
Q3LI83	Keratin-associated protein 24-1	DEG_SPOP_SBC_1	27:31	PVTSS	SPOP	0.9114	More...
Q2VYF4	LETM1 domain-containing protein LETM2, mitochondrial	DEG_SPOP_SBC_1	446:450	PVTSS	SPOP	0.9775	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5089:5093	PVTSS	SPOP	0.9713	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	3945:3949	PVTSS	SPOP	0.9405	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	1387:1391	PVTSS	SPOP	0.9755	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2252:2256	PVTSS	SPOP	0.9947	More...
Q13029	PR domain zinc finger protein 2	DEG_SPOP_SBC_1	727:731	PVTSS	SPOP	0.9999	More...
Q8NHV4	Protein NEDD1	DEG_SPOP_SBC_1	449:453	PVTSS	SPOP	0.9326	More...
Q9Y458	T-box transcription factor TBX22	DEG_SPOP_SBC_1	324:328	PVTSS	SPOP	0.753	More...
A0AVK6	Transcription factor E2F8	DEG_SPOP_SBC_1	679:683	PVTSS	SPOP	0.7433	More...
Q8NCT3	Uncharacterized protein KIAA0895	DEG_SPOP_SBC_1	157:161	PVTSS	SPOP	0.9394	More...
Q8ND82	Zinc finger protein 280C	DEG_SPOP_SBC_1	211:215	PVTSS	SPOP	0.805	More...

Showing 1 to 22 of 22 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVTSS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of PVTSS