DegronMD - Q9Y253(POLH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S450Y	TCGA-AG-A002	READ	TCGA	PVTSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1944
p.S450Y	SIDM00534	Colorectal Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1944
p.S450Y	ACH-000986	Colon/Colorectal Cancer	CCLE	PVTSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1944
p.S450Y	HT-115	large intestine	COSMIC	PVTSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1944
p.A433S	DO229032	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	433:437	Mutation altering degron motif	0.7588
p.S436T	DO23516	LIRI	ICGC	APSSS	DEG_SPOP_SBC_1	433:437	Mutation altering degron motif	0.6005
p.P448L	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PVTSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1389
p.P448L	ACH-002256	Leukemia	CCLE	PVTSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1389
p.P448L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PVTSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.1389
p.P455S	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PVTSS	DEG_SPOP_SBC_1	455:459	Mutation altering degron motif	0.6752
p.P455S	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PVTSS	DEG_SPOP_SBC_1	455:459	Mutation altering degron motif	0.6752
p.A469V	SIDM00562	Breast Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.0556
p.A469V	MRK-nu-1	breast	COSMIC	PVTSS	DEG_SPOP_SBC_1	455:459	Mutation rewiring degron network	0.0556
p.F429C	SIDM01588	Endometrial Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.2222
p.F429C	ACH-000993	Endometrial/Uterine Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	433:437	Mutation rewiring degron network	0.2222

Kaplan plot for POLH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

POLH

UniProt ID: Q9Y253

Entrez ID: 5429

Protein name: DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for POLH in