DegronMD - Q2VYF4(LETM2)

LETM2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T433M	TCGA-AG-4009	READ	TCGA	SKENM	DEG_APCC_KENBOX_2	422:426	Mutation rewiring degron network	0.1389
p.P417S	TCGA-AX-A1CE	UCEC	TCGA	SKENM	DEG_APCC_KENBOX_2	422:426	Mutation rewiring degron network	0.1944
p.P417S	DO42280	UCEC	ICGC	SKENM	DEG_APCC_KENBOX_2	422:426	Mutation rewiring degron network	0.1944
p.E423K	TCGA-CA-6717	COAD	TCGA	SKENM	DEG_APCC_KENBOX_2	422:426	Mutation altering degron motif	0.7022
p.E423K	TCGA-UE-A6QU	SARC	TCGA	SKENM	DEG_APCC_KENBOX_2	422:426	Mutation altering degron motif	0.7022
p.Q427R	TCGA-Z4-A9VC	SARC	TCGA	SKENM	DEG_APCC_KENBOX_2	422:426	Mutation rewiring degron network	0.3056
p.V447F	DO228948	LICA	ICGC	PVTSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.5957
p.K437N	DO37462	SKCM	ICGC	PVTSS	DEG_SPOP_SBC_1	446:450	Mutation substituting flanking lysine	0.1944
p.I452V	SIDM00074	Burkitt's Lymphoma	GDSC	PVTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778
p.I452V	SIDM00953	Small Cell Lung Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778
p.I452V	SIDM00950	Pancreatic Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778
p.I452V	SIDM00669	Pancreatic Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778
p.I452V	SIDM00150	Colorectal Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778
p.I452V	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	PVTSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc