DegronMD

Uniprot ID: Q2VYF4

Source protein: LETM1 domain-containing protein LETM2, mitochondrial

Source gene: LETM2

Class: DEG_APCC_KENBOX_2

Location: 422:426

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9329

ASA_SCORE: 100.28

COIL: 0.5884

CONS_SCORE: 0.5242

DSS_SCORE: 0.4596

HELIX: 0.3216

FCONS_SCORE: 1.2474

RIG_SCORE: 0.7578

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T433M	TCGA-AG-4009	READ	TCGA	SKENM	DEG_APCC_KENBOX_2	0.1389
p.P417S	TCGA-AX-A1CE	UCEC	TCGA	SKENM	DEG_APCC_KENBOX_2	0.1944
p.P417S	DO42280	UCEC	ICGC	SKENM	DEG_APCC_KENBOX_2	0.1944
p.E423K	TCGA-CA-6717	COAD	TCGA	SKENM	DEG_APCC_KENBOX_2	0.7022
p.E423K	TCGA-UE-A6QU	SARC	TCGA	SKENM	DEG_APCC_KENBOX_2	0.7022
p.Q427R	TCGA-Z4-A9VC	SARC	TCGA	SKENM	DEG_APCC_KENBOX_2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5BKX8	Caveolae-associated protein 4	DEG_APCC_KENBOX_2	203:207	SKENM	APC,CDC20,FZR1	0.9029	More...
Q2VYF4	LETM1 domain-containing protein LETM2, mitochondrial	DEG_APCC_KENBOX_2	422:426	SKENM	APC,CDC20,FZR1	0.9329	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons