DegronMD

Uniprot ID: Q5BKX8

Source protein: Caveolae-associated protein 4

Source gene: CAVIN4

Class: DEG_APCC_KENBOX_2

Location: 203:207

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9029

ASA_SCORE: 94.84

COIL: 0.3096

CONS_SCORE: 0.9411

DSS_SCORE: 0.5746

HELIX: 0.6852

FCONS_SCORE: 1.2164

RIG_SCORE: 0.7176

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S203Y	SIDM00789	Colorectal Carcinoma	GDSC	SKENM	DEG_APCC_KENBOX_2	0.6009
p.S203Y	HCT-15	large_intestine	COSMIC	SKENM	DEG_APCC_KENBOX_2	0.6009
p.D196A	SIDM00193	Colorectal Carcinoma	GDSC	SKENM	DEG_APCC_KENBOX_2	0.1389
p.D196A	SNU-81	large_intestine	COSMIC	SKENM	DEG_APCC_KENBOX_2	0.1389
p.K209N	SIDM00589	Oral Cavity Carcinoma	GDSC	SKENM	DEG_APCC_KENBOX_2	0.2778
p.K209N	HSC-3	upper_aerodigestive_tract	COSMIC	SKENM	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5BKX8	Caveolae-associated protein 4	DEG_APCC_KENBOX_2	203:207	SKENM	APC,CDC20,FZR1	0.9029	More...
Q2VYF4	LETM1 domain-containing protein LETM2, mitochondrial	DEG_APCC_KENBOX_2	422:426	SKENM	APC,CDC20,FZR1	0.9329	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons