DegronMD

Uniprot ID: O15018

Source protein: PDZ domain-containing protein 2

Source gene: PDZD2

Class: DEG_COP1_1

Location: 2254:2261

E3 ligase: COP1

DEGRON score: 0.9616

ASA_SCORE: 85.9

COIL: 0.8785

CONS_SCORE: 0.3181

DSS_SCORE: 0.5848

HELIX: 0.068

FCONS_SCORE: 0.924

RIG_SCORE: 0.7116

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2260K	TCGA-D3-A8GV	SKCM	TCGA	TSSVVPEA	DEG_COP1_1	0.7022
p.E2260K	DO219477	SKCM	ICGC	TSSVVPEA	DEG_COP1_1	0.7022
p.R2247Q	DO228483	BRCA	ICGC	TSSVVPEA	DEG_COP1_1	0.1389
p.R2247Q	DO229003	COCA	ICGC	TSSVVPEA	DEG_COP1_1	0.1389
p.R2247Q	DO229005	COCA	ICGC	TSSVVPEA	DEG_COP1_1	0.1389
p.R2247Q	DO230525	LUSC	ICGC	TSSVVPEA	DEG_COP1_1	0.1389
p.R2247Q	DO230554	LUSC	ICGC	TSSVVPEA	DEG_COP1_1	0.1389
p.V2258F	DO228948	LICA	ICGC	TSSVVPEA	DEG_COP1_1	0.7068
p.A2263S	DO229029	LICA	ICGC	TSSVVPEA	DEG_COP1_1	0.2778
p.R2245C	DO229062	LICA	ICGC	TSSVVPEA	DEG_COP1_1	0.0833
p.G2244V	SIDM00124	Kidney Carcinoma	GDSC	TSSVVPEA	DEG_COP1_1	0.0556
p.G2244V	ACH-000555	Kidney Cancer	CCLE	TSSVVPEA	DEG_COP1_1	0.0556
p.G2244V	A498	kidney	COSMIC	TSSVVPEA	DEG_COP1_1	0.0556
p.R2245H	ACH-001441	Eye Cancer	CCLE	TSSVVPEA	DEG_COP1_1	0.0833
p.R2245H	ACH-001559	Lung Cancer	CCLE	TSSVVPEA	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_COP1_1	2254:2261	TSSVVPEA	COP1	0.9616	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons