DegronMD

Uniprot ID: O15018

Source protein: PDZ domain-containing protein 2

Source gene: PDZD2

Class: LIG_APCC_ABBAyCdc20_2

Location: 1583:1589

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5397

ASA_SCORE: 115.3143

COIL: 0.8931

CONS_SCORE: 0.3275

DSS_SCORE: 0.6939

HELIX: 0.0739

FCONS_SCORE: 0.9214

RIG_SCORE: 0.6118

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1576S	TCGA-22-4593	LUSC	TCGA	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G1576S	DO27018	LUSC	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G1576S	DO222504	MELA	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G1576S	SIDM00781	Colorectal Carcinoma	GDSC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G1576S	SIDM00780	Colorectal Carcinoma	GDSC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.G1576S	SNU-C2B	large_intestine	COSMIC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.1389
p.R1583C	TCGA-2W-A8YY	CESC	TCGA	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R1583C	TCGA-EO-A22U	UCEC	TCGA	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R1583C	DO223732	CESC	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R1583C	DO232952	PEME	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R1583C	DO43755	UCEC	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R1581C	TCGA-BH-A0AY	BRCA	TCGA	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.R1581C	DO5025	BRCA	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.2778
p.K1588N	TCGA-BR-8361	STAD	TCGA	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.5806
p.K1588N	DO48032	STAD	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.5806
p.D1575N	TCGA-EE-A20C	SKCM	TCGA	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.D1575N	DO222775	MELA	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.D1575N	DO47665	SKCM	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E1597Q	TCGA-VS-A953	CESC	TCGA	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E1597Q	DO219727	CESC	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.1111
p.R1583H	DO234286	ESAD	ICGC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.8244
p.S1594L	SIDM01199	Hepatocellular Carcinoma	GDSC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.6389
p.S1594L	ACH-000493	Liver Cancer	CCLE	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.6389
p.S1594L	SNU-423	liver	COSMIC	RVSLHKE	LIG_APCC_ABBAyCdc20_2	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	LIG_APCC_ABBAyCdc20_2	1583:1589	RVSLHKE	APC,CDC20,FZR1	0.5397	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RVSLHKE

Degron related mutations and impact score

Drug responses associated with PDZD2 mutations

All proteins holding degron of RVSLHKE