DegronMD

Uniprot ID: O15018

Source protein: PDZ domain-containing protein 2

Source gene: PDZD2

Class: DEG_SCF_FBW7_1

Location: 2514:2521

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 104.375

COIL: 0.865

CONS_SCORE: 0.5212

DSS_SCORE: 0.558

HELIX: 0.0683

FCONS_SCORE: 1.3961

RIG_SCORE: 0.712

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2507T	TCGA-AA-3815	COAD	TCGA	LEITPRRS	DEG_SCF_FBW7_1	0.1389
p.A2507T	TCGA-E6-A2P9	UCEC	TCGA	LEITPRRS	DEG_SCF_FBW7_1	0.1389
p.A2507T	DO9924	COAD	ICGC	LEITPRRS	DEG_SCF_FBW7_1	0.1389
p.A2507T	DO43714	UCEC	ICGC	LEITPRRS	DEG_SCF_FBW7_1	0.1389
p.E2513K	TCGA-AC-A23H	BRCA	TCGA	LEITPRRS	DEG_SCF_FBW7_1	0.3056
p.E2513K	DO2401	BRCA	ICGC	LEITPRRS	DEG_SCF_FBW7_1	0.3056
p.V2508M	TCGA-AX-A1C7	UCEC	TCGA	LEITPRRS	DEG_SCF_FBW7_1	0.1667
p.V2508M	DO41115	UCEC	ICGC	LEITPRRS	DEG_SCF_FBW7_1	0.1667
p.S2530L	TCGA-E6-A1LX	UCEC	TCGA	LEITPRRS	DEG_SCF_FBW7_1	0.5278
p.S2530L	DO41020	UCEC	ICGC	LEITPRRS	DEG_SCF_FBW7_1	0.5278
p.K2511E	TCGA-HU-A4GU	STAD	TCGA	LEITPRRS	DEG_SCF_FBW7_1	0.3611
p.K2511E	DO47849	STAD	ICGC	LEITPRRS	DEG_SCF_FBW7_1	0.3611
p.R2520K	DO234445	ESAD	ICGC	LEITPRRS	DEG_SCF_FBW7_1	0.6126
p.R2520M	DO228952	LICA	ICGC	LEITPRRS	DEG_SCF_FBW7_1	0.7521
p.C2531F	DO229025	LICA	ICGC	LEITPRRS	DEG_SCF_FBW7_1	0.0556
p.P2524L	DO222363	MELA	ICGC	LEITPRRS	DEG_SCF_FBW7_1	0.25
p.V2529I	SIDM02039	Colorectal Carcinoma	GDSC	LEITPRRS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SCF_FBW7_1	2514:2521	LEITPRRS	FBXW7	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons