DegronMD

Uniprot ID: O15018

Source protein: PDZ domain-containing protein 2

Source gene: PDZD2

Class: DEG_SCF_FBW7_1

Location: 676:683

E3 ligase: FBXW7

DEGRON score: 0.9872

ASA_SCORE: 82.0375

COIL: 0.9143

CONS_SCORE: 0.548

DSS_SCORE: 0.4399

HELIX: 0.04

FCONS_SCORE: 1.0099

RIG_SCORE: 0.7076

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P693Q	TCGA-55-6979	LUAD	TCGA	PSLTPCST	DEG_SCF_FBW7_1	0.0556
p.P693Q	DO24110	LUAD	ICGC	PSLTPCST	DEG_SCF_FBW7_1	0.0556
p.S682L	TCGA-AJ-A3EK	UCEC	TCGA	PSLTPCST	DEG_SCF_FBW7_1	0.6556
p.S682L	TCGA-HU-8602	STAD	TCGA	PSLTPCST	DEG_SCF_FBW7_1	0.6556
p.S682L	DO47829	STAD	ICGC	PSLTPCST	DEG_SCF_FBW7_1	0.6556
p.S682L	DO41584	UCEC	ICGC	PSLTPCST	DEG_SCF_FBW7_1	0.6556
p.A691T	TCGA-BR-8081	STAD	TCGA	PSLTPCST	DEG_SCF_FBW7_1	0.1111
p.A691T	DO51478	PACA	ICGC	PSLTPCST	DEG_SCF_FBW7_1	0.1111
p.A691T	DO38795	STAD	ICGC	PSLTPCST	DEG_SCF_FBW7_1	0.1111
p.P693L	TCGA-D1-A2G0	UCEC	TCGA	PSLTPCST	DEG_SCF_FBW7_1	0.0556
p.P693L	TCGA-QG-A5YX	COAD	TCGA	PSLTPCST	DEG_SCF_FBW7_1	0.0556
p.P693L	DO44093	COAD	ICGC	PSLTPCST	DEG_SCF_FBW7_1	0.0556
p.P693L	DO43049	UCEC	ICGC	PSLTPCST	DEG_SCF_FBW7_1	0.0556
p.P680R	TCGA-E8-A417	THCA	TCGA	PSLTPCST	DEG_SCF_FBW7_1	0.7512
p.P680R	DO38898	THCA	ICGC	PSLTPCST	DEG_SCF_FBW7_1	0.7512
p.S675I	TCGA-EE-A2GN	SKCM	TCGA	PSLTPCST	DEG_SCF_FBW7_1	0.3056
p.S675I	DO37896	SKCM	ICGC	PSLTPCST	DEG_SCF_FBW7_1	0.3056
p.P693T	TCGA-EE-A2ME	SKCM	TCGA	PSLTPCST	DEG_SCF_FBW7_1	0.0556
p.P693T	DO38011	SKCM	ICGC	PSLTPCST	DEG_SCF_FBW7_1	0.0556
p.P680L	TCGA-ER-A19L	SKCM	TCGA	PSLTPCST	DEG_SCF_FBW7_1	0.7582
p.P680L	DO37587	SKCM	ICGC	PSLTPCST	DEG_SCF_FBW7_1	0.7582
p.T668M	TCGA-L5-A891	ESCA	TCGA	PSLTPCST	DEG_SCF_FBW7_1	0.1111
p.C681S	DO228862	LICA	ICGC	PSLTPCST	DEG_SCF_FBW7_1	0.643
p.R670C	SIDM00014	Colorectal Carcinoma	GDSC	PSLTPCST	DEG_SCF_FBW7_1	0.1667
p.R670C	LIM1215	large_intestine	COSMIC	PSLTPCST	DEG_SCF_FBW7_1	0.1667
p.R670H	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PSLTPCST	DEG_SCF_FBW7_1	0.1667
p.R670H	ACH-000937	Leukemia	CCLE	PSLTPCST	DEG_SCF_FBW7_1	0.1667
p.R670H	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PSLTPCST	DEG_SCF_FBW7_1	0.1667
p.S688G	SIDM01613	Colorectal Carcinoma	GDSC	PSLTPCST	DEG_SCF_FBW7_1	0.1944
p.S692F	ACH-002785	Unknown	CCLE	PSLTPCST	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSLTPCST

Degron related mutations and impact score

Drug responses associated with PDZD2 mutations

All proteins holding degron of PSLTPCST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15018	PDZ domain-containing protein 2	DEG_SCF_FBW7_1	676:683	PSLTPCST	FBXW7	0.9872	More...