DegronMD

Uniprot ID: Q9Y467

Source protein: Sal-like protein 2

Source gene: SALL2

Class: DEG_SCF_FBW7_1

Location: 298:303

E3 ligase: FBXW7

DEGRON score: 0.9808

ASA_SCORE: 87.2333

COIL: 0.9552

CONS_SCORE: 0.476

DSS_SCORE: 0.7186

HELIX: 0.0098

FCONS_SCORE: 1.1155

RIG_SCORE: 0.5727

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R294Q	TCGA-58-8387	LUSC	TCGA	PTPAPS	DEG_SCF_FBW7_1	0.2222
p.R294Q	TCGA-AZ-6598	COAD	TCGA	PTPAPS	DEG_SCF_FBW7_1	0.2222
p.R294Q	TCGA-B5-A11Y	UCEC	TCGA	PTPAPS	DEG_SCF_FBW7_1	0.2222
p.R294Q	TCGA-CV-A6JZ	HNSC	TCGA	PTPAPS	DEG_SCF_FBW7_1	0.2222
p.R294Q	TCGA-R6-A6KZ	ESCA	TCGA	PTPAPS	DEG_SCF_FBW7_1	0.2222
p.P302L	TCGA-FW-A3R5	SKCM	TCGA	PTPAPS	DEG_SCF_FBW7_1	0.6471
p.V307L	DO44037	BLCA	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.2222
p.P291T	DO223732	CESC	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.1389
p.N296S	DO233258	GACA	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.2778
p.S310C	DO228380	LICA	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.1389
p.P297Q	DO228952	LICA	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.3056
p.D305E	DO229025	LICA	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.2778
p.T309N	DO229008	LICA	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.1667
p.K289R	DO23314	LINC	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.0833
p.D305H	DO27074	LUSC	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.2778
p.P297L	DO47331	SKCM	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.3056
p.V292L	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PTPAPS	DEG_SCF_FBW7_1	0.1667
p.V292L	ACH-000929	Lung Cancer	CCLE	PTPAPS	DEG_SCF_FBW7_1	0.1667
p.V292L	NCI-H2110	lung	COSMIC	PTPAPS	DEG_SCF_FBW7_1	0.1667
p.P307S	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PTPAPS	DEG_SCF_FBW7_1	0.2222
p.P307S	ACH-000964	Leukemia	CCLE	PTPAPS	DEG_SCF_FBW7_1	0.2222
p.P304S	ACH-002287	Colon/Colorectal Cancer	CCLE	PTPAPS	DEG_SCF_FBW7_1	0.3056
p.Y306C	GP5d	large_intestine	COSMIC	PTPAPS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46695	Radiation-inducible immediate-early gene IEX-1	DEG_SCF_FBW7_1	17:22	PTPAPS	FBXW7	0.9989	More...
Q07157	Tight junction protein ZO-1	DEG_SCF_FBW7_1	959:964	PTPAPS	FBXW7	0.9995	More...
Q9H987	Synaptopodin 2-like protein	DEG_SCF_FBW7_1	457:462	PTPAPS	FBXW7	0.9753	More...
Q9Y467	Sal-like protein 2	DEG_SCF_FBW7_1	298:303	PTPAPS	FBXW7	0.9808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons