DegronMD

Uniprot ID: P46695

Source protein: Radiation-inducible immediate-early gene IEX-1

Source gene: IER3

Class: DEG_SCF_FBW7_1

Location: 17:22

E3 ligase: FBXW7

DEGRON score: 0.9989

ASA_SCORE: 80.4833

COIL: 0.9437

CONS_SCORE: 0.6353

DSS_SCORE: 0.6899

HELIX: 0.0198

FCONS_SCORE: 1.0621

RIG_SCORE: 0.629

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S31F	DO222498	MELA	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.5278
p.T23I	DO32831	PACA	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.3056
p.A16D	SIDM01112	Osteosarcoma	GDSC	PTPAPS	DEG_SCF_FBW7_1	0.3056
p.G32S	SIDM01121	Small Cell Lung Carcinoma	GDSC	PTPAPS	DEG_SCF_FBW7_1	0.0556
p.S22P	SIDM01608	Endometrial Carcinoma	GDSC	PTPAPS	DEG_SCF_FBW7_1	0.6752
p.R28W	ACH-000889	Myeloma	CCLE	PTPAPS	DEG_SCF_FBW7_1	0.1667
p.P9Q	ACH-000911	Gastric Cancer	CCLE	PTPAPS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46695	Radiation-inducible immediate-early gene IEX-1	DEG_SCF_FBW7_1	17:22	PTPAPS	FBXW7	0.9989	More...
Q07157	Tight junction protein ZO-1	DEG_SCF_FBW7_1	959:964	PTPAPS	FBXW7	0.9995	More...
Q9H987	Synaptopodin 2-like protein	DEG_SCF_FBW7_1	457:462	PTPAPS	FBXW7	0.9753	More...
Q9Y467	Sal-like protein 2	DEG_SCF_FBW7_1	298:303	PTPAPS	FBXW7	0.9808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons