DegronMD

Uniprot ID: Q07157

Source protein: Tight junction protein ZO-1

Source gene: TJP1

Class: DEG_SCF_FBW7_1

Location: 959:964

E3 ligase: FBXW7

DEGRON score: 0.9995

ASA_SCORE: 81.2

COIL: 0.9583

CONS_SCORE: 0.3674

DSS_SCORE: 0.6786

HELIX: 0.022

FCONS_SCORE: 1.2401

RIG_SCORE: 0.6141

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E957V	TCGA-13-1497	OV	TCGA	PTPAPS	DEG_SCF_FBW7_1	0.2778
p.E957V	DO31959	OV	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.2778
p.S968L	TCGA-55-8204	LUAD	TCGA	PTPAPS	DEG_SCF_FBW7_1	0.6667
p.S968L	DO45322	LUAD	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.6667
p.E958K	TCGA-A5-A0G2	UCEC	TCGA	PTPAPS	DEG_SCF_FBW7_1	0.3056
p.E958K	DO41235	UCEC	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.3056
p.Y967H	TCGA-B5-A3FA	UCEC	TCGA	PTPAPS	DEG_SCF_FBW7_1	0.6944
p.Y967H	DO52402	UCEC	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.6944
p.Y967H	HT-144	skin	COSMIC	PTPAPS	DEG_SCF_FBW7_1	0.6944
p.P959L	TCGA-DD-A1EH	LIHC	TCGA	PTPAPS	DEG_SCF_FBW7_1	0.6471
p.P959L	DO22986	LIHC	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.6471
p.P963S	TCGA-EE-A29E	SKCM	TCGA	PTPAPS	DEG_SCF_FBW7_1	0.5641
p.P963S	DO37831	SKCM	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.5641
p.S973Y	TCGA-EO-A22U	UCEC	TCGA	PTPAPS	DEG_SCF_FBW7_1	0.5278
p.S973Y	DO43755	UCEC	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.5278
p.S973Y	SIDM00193	Colorectal Carcinoma	GDSC	PTPAPS	DEG_SCF_FBW7_1	0.5278
p.S973Y	ACH-000991	Colon/Colorectal Cancer	CCLE	PTPAPS	DEG_SCF_FBW7_1	0.5278
p.S973Y	SNU-81	large_intestine	COSMIC	PTPAPS	DEG_SCF_FBW7_1	0.5278
p.L951V	DO222884	COCA	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.1111
p.V970A	ACH-000978	Endometrial/Uterine Cancer	CCLE	PTPAPS	DEG_SCF_FBW7_1	0.1667
p.V970A	EN	endometrium	COSMIC	PTPAPS	DEG_SCF_FBW7_1	0.1667
p.S971I	HCC2998	large_intestine	COSMIC	PTPAPS	DEG_SCF_FBW7_1	0.1389
p.S959I	HCC2998	large_intestine	COSMIC	PTPAPS	DEG_SCF_FBW7_1	0.7341
p.V954A	EN	endometrium	COSMIC	PTPAPS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46695	Radiation-inducible immediate-early gene IEX-1	DEG_SCF_FBW7_1	17:22	PTPAPS	FBXW7	0.9989	More...
Q07157	Tight junction protein ZO-1	DEG_SCF_FBW7_1	959:964	PTPAPS	FBXW7	0.9995	More...
Q9H987	Synaptopodin 2-like protein	DEG_SCF_FBW7_1	457:462	PTPAPS	FBXW7	0.9753	More...
Q9Y467	Sal-like protein 2	DEG_SCF_FBW7_1	298:303	PTPAPS	FBXW7	0.9808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons