DegronMD

Uniprot ID: Q9H987

Source protein: Synaptopodin 2-like protein

Source gene: SYNPO2L

Class: DEG_SCF_FBW7_1

Location: 457:462

E3 ligase: FBXW7

DEGRON score: 0.9753

ASA_SCORE: 85.95

COIL: 0.9415

CONS_SCORE: 0.5569

DSS_SCORE: 0.6936

HELIX: 0.0138

FCONS_SCORE: 0.9945

RIG_SCORE: 0.6083

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G454A	TCGA-HU-A4GU	STAD	TCGA	PTPAPS	DEG_SCF_FBW7_1	0.25
p.G454A	DO47849	STAD	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.25
p.A460V	TCGA-W3-AA1V	SKCM	TCGA	PTPAPS	DEG_SCF_FBW7_1	0.5825
p.A460V	DO51276	SKCM	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.5825
p.P459S	DO222454	BTCA	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.6752
p.P459S	DO233882	GACA	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.6752
p.S462I	DO6690	CLLE	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.7341
p.P461L	DO234401	ESAD	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.6471
p.P449R	DO229353	LAML	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.1111
p.A468D	DO231957	LICA	ICGC	PTPAPS	DEG_SCF_FBW7_1	0.1667
p.E458D	CW-2	large_intestine	COSMIC	PTPAPS	DEG_SCF_FBW7_1	0.6758

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46695	Radiation-inducible immediate-early gene IEX-1	DEG_SCF_FBW7_1	17:22	PTPAPS	FBXW7	0.9989	More...
Q07157	Tight junction protein ZO-1	DEG_SCF_FBW7_1	959:964	PTPAPS	FBXW7	0.9995	More...
Q9H987	Synaptopodin 2-like protein	DEG_SCF_FBW7_1	457:462	PTPAPS	FBXW7	0.9753	More...
Q9Y467	Sal-like protein 2	DEG_SCF_FBW7_1	298:303	PTPAPS	FBXW7	0.9808	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons